Impact of Endothelial and Leukocyte Senescence in Circulatory Shock States
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 520
- 试验地点
- 1
- 主要终点
- The main criterion will be the acquisition of a senescent phenotype concerning leukocytes and endothelial cells.
研究概览
简要总结
Circulatory shocks (CS) are life-threatening, acute organ dysfunction. Advances in critical care medicine have decreased early hospital mortality, increasing the number of surviving patients. Regrettably, these survivors are at increased risk of new infections but also of cardiovascular disease.
The investigators hypothesize that CS with multi-organ dysfunction is associated with premature senescence of endothelial cells and immune cells and promotes endothelial thrombogenicity and immunosenescence leading to cardiovascular disease and secondary infections.
The aim of this work is therefore to evaluate the contribution of endothelial and leucocytes senescence to the occurrence of secondary events (infectious and cardiovascular) in patients with a CS. It will provide a better understanding of the pathogenesis of cardiovascular and immune diseases following a CS, likely to guide new management strategies to prevent their occurrence.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Patients with circulatory shock
500 patients with circulatory shock hospitalize in ICU will be prospectively included to assess the effect of this pathology on the senescence phenotype
干预措施: Biological samples will be done to evaluate the endothelial and leukocyte senescence. (Biological)
Healthy volunteers
20 healthy volunteers will be included to assess the effect of no pathology on the senescence phenotype.
干预措施: Biological samples will be done to evaluate the endothelial and leukocyte senescence. (Biological)
结局指标
主要结局
The main criterion will be the acquisition of a senescent phenotype concerning leukocytes and endothelial cells.
时间窗: 1 year
Biological samples will be done to evaluate the endothelial and leukocyte senescence.
次要结局
- Incidence of cardiovascular events and secondary infection in hospitalized patients in intensive care unit for circulatory shock states(5 years)