Comparison of the effect of eicosapentaenoic acid and docosahexaenoic acid on the treatment of depressio
- Conditions
- Recurrent depressive disorder.Recurrent depressive disorder
- Registration Number
- IRCT201010054873N1
- Lead Sponsor
- Research Accessory of Shahid Sadughi University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 81
ages between 18-75 years; a Beck Depression Inventory II score of 10-28; a Hamilton Rating Scale for Depression score of 8-18; no changes in doses or types of antidepressant medications within 4 weeks prior to the study entry; diagnose of mild to moderate depression with structured clinical interview by a psychiatrist according to DSM-IV-TR criteria
Exclusion criteria: diagnosis of any co-morbid mental disorder other than depression, serious suicidal or homicidal thoughts; use of fish oil or omega, supplements within the last 6 months or having taken more than 3 servings per weeks of fish; any changes in doses or types of current antidepressant medications within study period or use of psychotropics, anticonvulsants, mood stabilizers, and anticoagulants; cupping or blood coagulation disorders, gastrointestinal absorption disorders, and eating disorders; allergy to sea foods or study drugs, and history of multiple adverse drug reactions; history of electroconvulsive therapy or severe medical disorders that may lead in depression including cardiovascular, hepatic, renal, respiratory, and endocrine diseases; smoking and drug or alcohol abuse; pregnancy or breastfeeding; serious adverse effects and incompliance to study protocol
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of depression. Timepoint: Weeks 0, 6, and 12. Method of measurement: Hamilton Rating Scale for Depression.
- Secondary Outcome Measures
Name Time Method Remission. Timepoint: Week 12. Method of measurement: Hamilton Rating Scale for Depression.