Comprehensive detection of childhood cancer predisposing genes using exome sequencing: The next step towards personalized treatment and cancer prevention.
- Conditions
- kanker op de kinderleeftijdchildhood cancerpediatric tumors1002766410027655
- Registration Number
- NL-OMON37736
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 180
Inclusion Criteria
Individuals diagnosed with any form of childhood cancer and one of the following characteristics will be included:
• Intellectual disability,
• Congenital anomalies,
• Adult type of cancer in a child
• First or second degree relative with the same type of cancer.
• Second primary malignancy
as well as their parents
Exclusion Criteria
A known genetic defect in the family for a cancer unrelated condition, of which the child might be a carrier but about which the child/parents do not want to be informed.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Mutations in known and novel pediatric cancer predisposing genes.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The results of this exome sequencing project will likely result in novel<br /><br>clinical, molecular genetic, and functional studies in order to explore the<br /><br>impact on clinical practice and to investigate novel functional pathways in<br /><br>childhood cancer initiation and development. </p><br>