Retrospective analysis of patients with stage IV non-squamous lung cancer with and without TTF-1- and KRAS-G12-mutatio

• Conditions: C34; Malignant neoplasm of bronchus and lung

• Registration Number: DRKS00023890
• Lead Sponsor: Krankenhaus Martha-Maria Halle-Dölau

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-17
• Study Completion: 2021-04-01
• Results First Posted: 2022-08-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 207

Inclusion Criteria

histologically confirmed non-squamous lung cancer stage IV. Patients from 2016-2019 follow up until the end of 2020

Exclusion Criteria

missing mutation analysis, other mutations

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall survival, calculated from the dates of histological confirmation until the date of death. We will analyse this date (time to event) using a Kaplan-Meier curve and hazard ratio, mean value and log-rank-test.

Secondary Outcome Measures

Name	Time	Method
Percentage of patients expressing the mutations and their specific subtype (KRAS-G12D, G12C,...). Correlation between KRAS/TTF-1 and smoking?