Neuromodulation With Spinal Stimulation Methods
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Spinal Cord Injuries
- Sponsor
- University of Manitoba
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Motor evoked potentials
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This is a pilot research study to test the protocols needed for transcutaneous spinal electrical stimulation in persons living with spinal cord injury (SCI). Up to 24 participants will be enrolled. A variety of stimulation parameters and outcome measures will be assessed.
Detailed Description
Purpose of this project Spinal cord stimulation has the potential to improve motor function recovery after spinal cord injury. Commonly used approaches include low-intensity, direct current (DC) stimulation applied across multiple segments, electrical transcutaneous (ETC) stimulation, and magnetic transcutaneous stimulation (MTC). Objective: to evaluate and compare the voluntary and reflexive motor performance in the same subjects, including people with and without spinal cord injury, after non-invasive spinal cord stimulation interventions. Comparing two different interventions applied in different experimental sessions and the respective sham stimulation is the goal of this study. corticospinal and spinal motor pathways in paraplegics and in non-injured humans will be tested.
Investigators
Eligibility Criteria
Inclusion Criteria
- •spinal cord injury C4 to L4
- •ability to understand and follow directions
Exclusion Criteria
- •history of seizures, head injury, concussion, unexplained loss of consciousness or if they lived with an implanted cochlear stimulator, brain/neurostimulator, cardiac pacemaker, medication infusion device or live with metal implants in their body or if they are pregnant.
Outcomes
Primary Outcomes
Motor evoked potentials
Time Frame: Immediately after stimulation (within 1-15 min)
MEP input-output curve
Motor response
Time Frame: Immediately after stimulation (within 1-15 min)
H-reflex input output curve
Secondary Outcomes
- Blood pressure(During the procedure/stimulation and up to 15 min after stimulation.)
- Perception of discomfort due to stimulation(During and after procedure/stimulation and up to 15 min after stimulation.)