Does a different number, phenotype and/or function of regulatory T cells contribute to the development of asthma?

Completed

• Conditions: bronchusobstruction; recurrent infant wheezing; 10038686; 10003816; 10006436

• Registration Number: NL-OMON31752
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 175

Inclusion Criteria

patient is early wheezer
patient is 3 years of age

Exclusion Criteria

The use of systemic immune modulating medication at the time of blood withdrawal and/or 6 weeks before blood withdrawal. The presence of an active infection at the time of blood withdrawal.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Study endpoint: transient or persistent wheezing (= asthma) at age 6 years.<br /><br>Study determinants: number, phenotype and functionality of regulatory T cells<br /><br>in the peripheral blood of early wheezers at age 3 and 5 years. Details on<br /><br>study determinants will be based on the outcome of the pilotstudy (Regulatory T<br /><br>cells in asthma; ABR nummer 19836) preceding the analysis of the samples of<br /><br>this prospective study.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary determinants:<br /><br>Questionnaires: WRC (Weekly Record Card) and questionnaire based upon the ISAAC<br /><br>and PIAMA studies.<br /><br>Lung function: RINTat the age of 3,4,5 and 6 years of age; Volume flow curves<br /><br>before and after &beta;2-mimetics at the age of 6 years.<br /><br>eNose measurement at the age of 3 and 6 years.<br /><br>Peripheral blood: cell numbers and Immunoglobin E levels (total and specific<br /><br>IgE for most common food and inhalent allergens).</p><br>