MSCs Therapy for Cerebral Palsy
- Conditions
- Stem Cell Transplant Complications
- Interventions
- Other: stem cells
- Registration Number
- NCT04653077
- Lead Sponsor
- Aljazeera Hospital
- Brief Summary
Cerebral palsy (CP) is the most common physical disability in childhood. CP comprises a heterogeneous group of disorders that are the result of a non-progressive disruption or injury that occurred during fetal brain development or within the first two years of life.
- Detailed Description
This disruption can result in spasticity, dystonia, muscle contractures, weakness and difficulty in coordination that ultimately affects the ability to control movements. Resultant activity limitations may affect gross motor movements, fine motor movements, speech and communication, as well as eating and drinking.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
-
• Must be more than 2 year of age and less than 12 years of age at the time of screening for inclusion in the study.
- Clinical evidence of a non-progressive motor disability due to brain dysfunction.
-
• Intractable seizures
- Traumatic brain injury
- Genetic disorder
- Current Infection
- Renal insufficiency
- Hepatic disease
- HIV+ (as demonstrated by positive blood test)
- Immunosuppression
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description stem cells stem cells Intravenous and Intrathecal transplantation of specific populations of purified bone marrow-derived stem cells and mesenchymal stem cells.
- Primary Outcome Measures
Name Time Method Changes in Motor Performance. 6 months the number of patients who will have changes in motor performance
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Aljazeera( Al Gazeera) hospital
🇪🇬Giza, Egypt