The neural correlates of action-perception coupling in schizophrenia: Impaired recalibration and cross-modal transfer of forward model predictions.

Not Applicable

Recruiting

Conditions: F20
F22
F23
F25
F28
F29
Schizophrenia
Persistent delusional disorders
Acute and transient psychotic disorders
Schizoaffective disorders

Registration Number: DRKS00025885

Lead Sponsor: niversitätsklinikum Gießen und Marburg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 48

Inclusion Criteria

Patient group: diagnosis from the schizophrenia spectrum (see investigated disease/health problem)
- Right-handedness
- Informed consent

Exclusion Criteria

- Contraindications for fMRI and/or tDCS.
- Brain injury or diagnosis of a medical or neurological disorder that could affect brain metabolism
- Non-correctable visual or auditory impairments
- Acute substance abuse
- Diagnosis from the schizophrenia spectrum in a first-degree relative (control group)
- Psychiatric diagnosis in the present or past (control group)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In both parts of the study: <br>- Comparison of experimentally assessed sensorimotor recalibration effects between patients with schizophrenia and healthy control subjects. <br>Study part 1 (fMRI): <br>- Comparison of changes in neural activity due to sensorimotor recalibration (especially in the cerebellum and sensory areas) between patients with schizophrenia and healthy control subjects.<br>Study part 2 (tDCS): <br>- Improvements in recalibration effects in active conditions by tDCS of the cerebellum in patients with schizophrenia and healthy control subjects compared to the sham control condition. <br>- Improvements in delay detection performance for active and passive conditions by tDCS of the angular gyrus in patients with schizophrenia and healthy control subjects compared to the sham control condition.<br>- Increased active-passive differences by tDCS of the SMA in patients with schizophrenia compared to the sham control condition.<br><br>

Secondary Outcome Measures

Name	Time	Method
- Comparison of recalibration effects between patients with schizophrenia showing hallucinations and ego-disturbances with patients without these symptoms.<br>- Correlation of the extent of negative and positive symptoms (assessed by SANS and SAPS) with the extent of recalibration effects.<br>