on-invasive follow-up assessment of brain involvement in Duchenne muscular dystrophy

Completed

Conditions: Duchenne Muscular Dystrophy
10029317

Registration Number: NL-OMON33784

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 51

Inclusion Criteria

Boys and men with DNA proven Duchenne muscular dystrophy. age: 8 years or older who previously participated in the study.
Healthy controls: boys 8 years or older and adults who previously participated in the study.

Exclusion Criteria

contra-indication for MRI
patients known with central nervous system disorder (epilepsy, tumor)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-Primary objectives<br /><br>Quantitative assessment of pathological changes in brain associated with<br /><br>dystrophin absence and cognitive impairment by:<br /><br>Comparison of DMD patients and healthy age matched controls by assessment of<br /><br>the following quantitative MR parameters:<br /><br>- cortical thickness<br /><br>- differences in grey and white matter volumes<br /><br>- cerebral perfusion, especially in the cerebellum<br /><br>- anatomical connectivity<br /><br>- functional connectivity<br /><br>- metabolism as assessed by MR spectroscopy of the cerebellum, hippocampus,<br /><br>amygdala and frontal cortex.<br /><br>The difference between the two timepoints per parameter per patient will be<br /><br>determined and consequently compared between patients and controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives<br /><br>To study the relationship between the above mentioned MR parameters and:<br /><br>- the results from neuropsychological testing and behavioral functioning</p><br>