Is more aggressive resection of the aorta for ascending aortic aneurysm safe and effective when compared to a less aggresive surgical approach?

Not Applicable

Completed

• Conditions: ascending aortic aneurysm; Surgery - Surgical techniques; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12619001583134
• Lead Sponsor: Cardiology Research Institute, Tomsk National Research Medical Center

Brief Summary

Objective. The aim of the study was to analyze early and mid-term results of non-Hemiarch and Hemiarch repair in patients with ascending aortic aneurysm. Methods. One hundred and fifty-one patients underwent elective ascending aortic replacement only for nonsyndromic aneurismal disease between January 2008 to December 2018 were retrospectively reviewed. All data were prospectively collected and recorded. All surgeries were performed concurrently in the same time period. Surgeons who performed these operations were experienced with both circulatory arrest and clamped aortic anastomoses The total patient population (n=151) was divided into 2 groups of patients. The first group of the patients (n=40) underwent ascending aortic replacement with a distal cross-clamp. The second group of the patients (n=111) underwent hemiarch repair using open distal aortic anastomosis. Results. There were nonsignificant difference between the groups in mortality rate and frequency of the nuerologic deficit as well as pulmionary complications, postoperative bleeding and acute kidney injury. Conclusion. Hemiarch repair is an effective and safe surgical treatment of ascending aortic aneurysms . This approach does not increase the risks of cardiac, neurological, pulmonary, hemorrhagic complications in the early postoperative period compared with ascenrdng aortic replacement. Midterm results are comparable between the groups.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-12-12
• Study Start: 2019-11-18
• Last Update Posted: 25 November 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 151

Inclusion Criteria

Patients with nonsyndromic ascending aortic aneuysm

Exclusion Criteria

Oncological disease (high degrees)
Refusal of surgical treatment

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Operative mortality as assessed by data linkage to medical records[During the first 30 days after the procedure];all-cause mortality as assessed by data linkage to medical records or or phone contact with relatives or physicians [Up to 5 years]