Clinical Predictors of Pediatric Obstructive Sleep Apnea/Hypopnea Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pediatric Sleep Apnea
- Sponsor
- Chang Gung Memorial Hospital
- Enrollment
- 88
- Locations
- 1
- Primary Endpoint
- Clinical predictors for apnea/hypopnea index (AHI)
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to develop adequate and satisfactory tools using reliable clinical and physical factors in predicting pediatric obstructive sleep apnea/hypopnea syndrome (OSAHS) and allow greater access to appropriate therapy in children.
Detailed Description
The prevalence of OSAHS is estimated to be about 1% to 4% in children, however, it is frequently underdiagnosed because of the difficulties for evaluation.Current diagnostic approaches are based on the patient's history, clinical presentation and physical examination, endoscopy, and radiological imaging examinations, and confirmation is made by the current gold standard of full-night polysomnography (PSG). Previous studies have reported the use of a clinical history, physical examination and questionnaires for predicting pediatric OSAHS but there were lacking of adequate and satisfactory results. Despite the potential diagnostic benefits, PSG for pediatric patients are not routinely used in clinical practice. Therefore, to obtain a reliable, valid, and easily-performed diagnostic or screening tool for the clinical assessment of pediatric OSAHS is essential for the cost-effective care of these patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •children (younger than 18 years old and older than 2 years old) with symptoms of snoring and then were confirmed to having obstructive sleep apnea/hypopnea syndrome by a comprehensive polysomnography
Exclusion Criteria
- •patients with substance abuse problems or the long-term usage of medications known to affect sleep, craniofacial abnormalities or neuromuscular disorders, Down syndrome, cerebral palsy, mucopolysaccharidoses, Prader-Willi syndrome, history of psychosis, central sleep apnea syndrome, or previous airway surgery including tonsillectomy and/or adenoidectomy were excluded from the study.
Outcomes
Primary Outcomes
Clinical predictors for apnea/hypopnea index (AHI)
Time Frame: up to 4 months
When all variables were analyzed individually with the AHI, Spearman rank correlation analysis was used to explore the relationships between clinical predictor variables and AHI.Significant variables were entered into stepwise multiple linear regression analysis to identify independent predictors for pediatric OSAHS and to develop a predictive equation for AHI values.
Secondary Outcomes
- Anthropometric measurements: tonsil size grading(up to 4 months)
- Anthropometric measurements: modified Mallampati grade (aka updated Friedman's tongue position(up to 4 months)
- Apnea/hypopnea index (AHI)(up to 4 months)
- Anthropometric measurements: body mass index z-score (BMI z-score)(up to 4 months)
- Snoring visual analogue scale (Snoring VAS)(up to 4 months)
- Anthropometric measurements: uvular length(up to 4 months)