Circulating blood cell populations in pateints with Diabetes mellitus and coronary artery disease: studies on cellular functions

Recruiting

• Conditions: 10011082; coronary artery disease; diabetes mellitus; 10018424

• Registration Number: NL-OMON30945
• Lead Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 136

Inclusion Criteria

•Diabetes mellitus: Diabetes type II, compensated with diet and/or oral medication.
•CAD: History of coronary artery disease >2 years, no myocardial infarction in the last 6 months.
•AMI: >3-fold increase of CK (CK-MB) levels. Patients with coronary artery disease in their early period after Acute Myocardial Infarction (day 4 - 7 post-infarction) will be recruited.
•Controls: patients diagnosed with hypertension, arrhythmias and/or heart valvular diseases; subjects should be age-matched with the above mentioned groups (subjects <45 years or >75 years old will be excluded).

Exclusion Criteria

•Anemia (Hb<8 g/L)
•Acute infectious diseases (e.g., pneumonia, urinary tract infections, anaphylactic shock etc.)
•Acute inflammation other than AMI (elevated leukocyte number)
•Acute conditions (surgery, stroke, thromboembolism etc)
•Single or multiorgan failure (heart failure NYHA III/IV, lung, liver, kidneys)
•Chronic inflammatory diseases (chronic kidney diseases, rheumatoid arthritis)
•Malignant diseases (or recent history of malignant diseases <1 year)
•Malignant arterial hypertension
•Hormonal treatment (thyroid hormones-T3/T4 not included) or anti-inflammatory drugs
•Genetic disorders (Down syndrome, X&Y chromosome syndrome), family hypercholesterolemia, genetic dyslipidemia
•Psychiatric abnormalities

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Possible differences between the study groups in number, phenotype or function<br /><br>will be statistically analyzed.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>