To compare the efficacy of dexmedetomidine and fentanyl as adjuncts to intrathecal 0.5% hyperbaric levobupivacaine for spinal anaesthesia in patients undergoing total abdominal hysterectomy

Phase 4

Not yet recruiting

• Conditions: Health Condition 1: N711- Chronic inflammatory disease of uterus

• Registration Number: CTRI/2023/08/056887
• Lead Sponsor: Rajendra Institute of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 September 2023

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Patient’s consent

Patients posted for elective total abdominal hysterectomy at Rajendra Institute of Medical Sciences

ASA physical status I & II

Exclusion Criteria

Patient’s with contradictions to spinal anaesthesia, neurological diseases, allergy or intolerance to local anaesthetic agents or other agents used for the study.

Presence of co-morbidities like severe anaemia, uncontrolled diabetes mellitus, asthma, uncontrolled hypertension, severe cardiac disease

Patient’s belonging to ASA III and above

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Comparison of sensory block achieved at T10 level after induction. <br/ ><br>2. Duration of sensory block <br/ ><br>3. Onset of motor block <br/ ><br>4. Duration of motor blockTimepoint: 1. From the time of induction to time taken to reach T10 dermatome. <br/ ><br>2. From the time of induction till patient feels the sensation at S1 dermatome. <br/ ><br>3. From the time of induction till patient attains modified Bromage scale grade 1 motor blockage. <br/ ><br>4. From the time of induction till patient attended complete motor recovery.

Secondary Outcome Measures

Name	Time	Method
1. To calculate the total duration of analgesia & consumption of rescue analgesia. <br/ ><br>2. To study the hemodynamic changes like HR, SBP, DBP, MAP, RR side effects & complications, if any.Timepoint: 1. Total rescue analgesia forfirst 24hours. <br/ ><br>2. Hemodynamic changes every 3 mins till first 15mins, every 5 mins for 1hr, every hourly for first 6 hours, then 6 hourly for first 24hours. <br/ ><br>3. Complications if any for first 24hours.