to compare the effect of nalbuphine vs fentanyl for haemodynamic stability in general anaesthesia.
Phase 4
- Conditions
- Health Condition 1: null- patients undergoing surgery which require general anaesthesia
- Registration Number
- CTRI/2017/07/008962
- Lead Sponsor
- Department of Anaesthesiology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Informed written consent for participation in study
Age: 20 to 60 years.
Either gender
ASA physical status I and II.
Patients posted for elective surgery for 2 hour duration, under general
anaesthesia, requiring endotracheal intubation.
Exclusion Criteria
Patient refusal to participate in study.
Hypersensitivity to drug.
Patients with anticipated difficult airway.
Patient with cardiac, pulmonary, neurologic, kidney diseases.
Patients on drugs like sedatives, opioids and anti-psychiatric drugs.
Intubation attempt lasting longer than 20 seconds.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the efficacy and safety of nalbuphine and fentanyl in <br/ ><br>attenuating <br/ ><br> <br/ ><br> <br/ ><br>haemodynamic stress response to laryngoscopy and endotracheal <br/ ><br> <br/ ><br> <br/ ><br> <br/ ><br>intubation. <br/ ><br> <br/ ><br> <br/ ><br>Timepoint: base line,study drug injection,2min,5min,10min,during laryngoscopy and intubation,1min,3min,5min,10min,15min,20min,30min,45min,60min,90min,120min,after extubation
- Secondary Outcome Measures
Name Time Method To assess the sedative effect of nalbuphine and fentanyl <br/ ><br> <br/ ><br> <br/ ><br>To observe complication if any, in two groups.Timepoint: base line,study drug injection,2min,5min,10min,during laryngoscopy and intubation,1min,3min,5min,10min,15min,20min,30min,45min,60min,90min,120min,after extubation