Can physical activity prevent the associated vascular dysfunction in type 2 diabetes?

Not Applicable

Recruiting

• Conditions: Type 2 diabetes; Cardiovascular - Other cardiovascular diseases; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12614000614695
• Lead Sponsor: Australian Catholic University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-06-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

60 participants aged 18-65 years old will be recruited: 30 healthy sedentary (< 2 hours of scheduled physical activity per week) controls, and 30 sedentary T2D patients. Participants will be matched on age, sex and BMI of T2D participants, to focus on the specific effect of T2D.

Exclusion Criteria

Participants will be excluded based on any of the following: cardiovascular disease or history, smoking, more than 5% weight gain or loss in the last 6 months; or use of vasodilator medication.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Microcirculatory endothelial function will be assessed on forearm skin by Laser Speckle Contrast Imaging incorporating transdermal iontophoresis of vasoactive drugs (Acetylcholine, Insuline). [End of intervention (12 weeks after participants started the physical activity program) and end of detraining period (week 24, 12 weeks after participants ended the physical activity program). ]

Secondary Outcome Measures

Name	Time	Method
Microcirculatory smooth muscle cell function will be assessed on forearm skin by Laser Speckle Contrast Imaging incorporating transdermal iontophoresis of vasoactive drug (sodium nitroprusside). [End of intervention (12 weeks after participants started the physical activity program) and end of detraining period (week 24, 12 weeks after participants ended the physical activity program). ]