Ayurvedic Management of Vitiligo

Phase 2/3

Not yet recruiting

• Conditions: Vitiligo. Ayurveda Condition: SVITRAH,

• Registration Number: CTRI/2023/04/051426
• Lead Sponsor: All India Institute of Ayurveda New Delhi

Brief Summary

INTRODUCTION:

 Vitiligo is a common dermatological disorder of chronic depigmentation which is phenotypically characterized by white macules on the skin caused as a result of the systematic destruction of functional melanocytes. It is reported to have a global prevalence of 1% and an Indian incidence of 0.2 to 8.8%. Its common age of onset is 10 to 30 years. It affects both the genders almost equally, but females show earlier ages of onset, hence their predominance being marked in the childhood vitiligo.The exact etiology of vitiligo is poorly understood and is often considered as a multifactorial disease with a complex pathogenesis encompassing several postulations implicating autoimmune, cytotoxic, biochemical, oxidant–antioxidant, viral, and neural mechanisms for destruction of the melanocyte function in genetically predisposed. It is classified into two classes segmental and non-segmental. There is a probable symmetry in the location of patches in non-segmental type of Vitiligo. This class includes generalized, Universal, Focal, Acrofacial and Mucosal Vitiligo. Latter is static and mostly affects the area of skin attached with dorsal root of spinal cord unilaterally.

 OBJECTIVES: PRIMARY:Reduction in subjective symptoms, Vitiligo Extensive Tensity Index (VETI) score and increase in repigmentation among pediatric patients of 10-16 years age group of Shvitra(vitiligo) on giving virechana along with *Manjishtadi Kashaya*, *Siva Gutika* and *Gandhakadi* *Lepa* and only *shamana chikitsa* for the duration of 60 days.

         SECONDARY: Improvement in Children’s Dermatological Life Quality Index (CDLQI) among pediatric patients of 10-16 years age group of Shvitra (vitiligo) on giving virechana along with *Manjishtadi Kashaya*, *Siva Gutika* and *Gandhakadi* *Lepa* and only *shamana chikitsa* for the duration of 60 days.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-05
• Last Update Posted: 2023-04-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• Children of age group 10-16 years of either gender Patients with Sadhya Lakshana of Shvitra Patients having Shvitra patches with normal tactile sensation.
• Patients who are willing to participate in study.

Exclusion Criteria

• Patients on any other oral/tropical medication.
• Vitiligo associated with malignant melanoma, albinism, and psoriasis.
• Patient suffering from other systemic diseases & autoimmune disorders.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in subjective symptoms, Vitiligo Extensive Tensity Index (VETI) score and increase in repigmentation	1st day | 61st day | 91st day

Secondary Outcome Measures

Name	Time	Method
Improvement in Children’s Dermatological Life Quality Index (CDLQI)	1st day

Trial Locations

Locations (1)

All India Institute of Ayurveda New Delhi; 🇮🇳 Delhi, DELHI, India

All India Institute of Ayurveda New Delhi

🇮🇳Delhi, DELHI, India

Dr Chinmay Dhananjay Chaudhari

Principal investigator

9011173228

chaudharichinu1996@gmail.com