Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study

Not yet recruiting

• Conditions: Cirrhosis; Intensive Care Medicine; Acute on Chronic Liver Failure(ACLF)

• Registration Number: NCT06948565
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

Ten years after our team's publication, practices have changed considerably in the management of severe cirrhotic patients. This study will analyse these practices in primary care hospitals and in a tertiary centre, and assess the impact of these changes on the prognosis of these patients.

The following hypotheses will be tested:

* Improvement in intensive care and overall prognosis compared with data from the literature prior to 2014

* Improved access to liver transplantation compared with the literature prior to 2014

* Improvement in intensive care unit practices (for example: application of recommendations published by learned societies concerning the intensive care unit management of patients with cirrhosis, access to comfort care, degree of clinical severity on admission to the intensive care unit, etc.).

* Centre' effect: variability in the phenotype of patients admitted to intensive care depending on the technical facilities available and whether or not the hospital centre has access to TH.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-11
• Study First Submitted: 2025-01-03
• Study First Submitted QC: 2025-04-24
• Last Update Submitted: 2025-04-24
• Study First Posted: 2025-04-29
• Last Update Posted: 2025-04-29
• Study Start: 2025-05
• Primary Completion: 2025-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Patients with cirrhosis over 18 years of age (cirrhosis either histologically proven or diagnosed by hepatologists according to clinical, biological and ultrasound criteria) admitted to intensive care between January 2014 and December 2024.

Exclusion Criteria

None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
28-day survival	28 days

Secondary Outcome Measures

Name	Time	Method
Phenotype of patients admitted to intensive care	baseline
Overall survival	through study completion
Survival without liver transplantation	12 months
Proportion of patients listed for liver transplantation	through study completion
number of patients receiving LT	through study completion
Prognostic performance of general and cirrhosis-specific organ failure scores	baseline
Comparison of the characteristics of patients on admission in primary care hospitals and in university hospital.	baseline

Trial Locations

Locations (1)

CHU de Besançon; 🇫🇷 Besançon, France