Comparison of ondansetron-dexamethasone-dimenhydrinate and ondansetron-dexamethasone to prevent postoperative nausea and vomiting after gynecologic laparoscopic surgery

Phase 4

Completed

• Conditions: postoperative nausea and vomiting; postoperative nausea and vomiting after gynecologic laparoscopic surgery; Dimenhydrinate; nausea vomiting; nausea and vomiting; PONV

• Registration Number: TCTR20210128001
• Lead Sponsor: Faculty of Medicine, Khon Kaen University

Brief Summary

no difference of the efficacy between ondansetron-dexamethasone-dimenhydrinate and ondansetron-dexamethasone in patient underwent gynecologic laparoscopic surgery

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-06-09
• Study Start: 2021-01-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

1 Women age 18-60 years old
2 ASA classification I-II
3 undergoing elective gynecologic laparoscopic surgery
4 Non smoker

Exclusion Criteria

1 patients with hypersensitivity or contraindication to the study drugs
2 receiving an antiemetic drug or steroid within 24 hrs before anesthesia
3 History of opioids use
4 Pregnancy
5 Psychologic problems
6 Operation change from laparoscopy to open surgery
7 Refuse to participate

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence and severity of postoperative nausea and vomiting at 30, 60 min, 8, 24 hours after surgery 30 min 60 min 8 hours 24 hours postoperative PONV severity grading

Secondary Outcome Measures

Name	Time	Method
Adverse effects of dimenhydrinate at 30, 60 min, 8, 24 hours after surgery 30 min 60 min 8 hours 24 hours postoperative drowsiness, dizziness, dryness of mouth