Fentanyl Test Results and Its Association With Morphine Requirements in Children With Obstructive Sleep Apnea Syndrome After Adenotonsillectomy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Rescue Morphine Requirement
Study Overview
Brief Summary
The purpose of this study is to discuss the relationship between the result of fentanyl test and required dosage of morphine for children with OSAS after adenotonsillectomy；and to evaluate the ability of predicting requested dosage of morphine postoperatively.
Detailed Description
All the patients were intubated. Sevoflurane was used for maintenance without any opioids. Before the end of the procedure, spontaneous respiratory was recovered. All the patients were given 1 mcg/kg fentanyl i.v. after the end of the procedure. The positive result was defined as spontaneous respiratory rate decreased more than 50%, the others were defined as negative result. All the patients were given morphine for pain relief according to our protocol after extubation.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 3 Years to 7 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •meet all of the following
- •the American society of anesthesiologists (ASA) class Ⅰ ~ Ⅱ
- •the age of 3 ~ 7 years old
- •children who underwent selective adenotonsillectomy.
Exclusion Criteria
- •meet anyone of the following
- •craniofacial malformations
- •mental retardation
- •BMI > 22 kg/m2
- •a history of bronchial asthma
- •a recent history of opioid use.
Outcomes
Primary Outcomes
Rescue Morphine Requirement
Time Frame: average 1 hour from extubation
Secondary Outcomes
- Number of Participants With Pulse Oxygen Saturation Less Than 95 Percent(average 1 hour from extubation)
- Post-operative Nausea and Vomiting(average 1 hour from extubation)
Investigators
Xuan Wang
Doctor
Children's Hospital of Fudan University