Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population. The Paris Prospective Study III
概览
- 阶段
- 不适用
- 干预措施
- Spider flash ECG, high-precision carotid echo-tracking, step test
- 疾病 / 适应症
- Community Based Study
- 发起方
- Institut National de la Santé Et de la Recherche Médicale, France
- 入组人数
- 10157
- 试验地点
- 1
- 主要终点
- cardiovascular disease (CVD)
- 状态
- 进行中（未招募）
- 最后更新
- 2个月前
概览
简要总结
The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.
详细描述
Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.
研究者
入排标准
入选标准
- •50-75 years, French speaking, given consent for genetic analysis,
- •written consent for participating in the study
排除标准
- •\<50 years and \>75 years,
- •no French speaking,
- •current pregnancy,
- •chronic severe disease,
- •disagreement for genetic analysis,
- •step test considered as non possible or non advisable by medical decision.
研究组 & 干预措施
general population
Observational study of 10157 adult men and women from the general population who benefited from a free extensive health check up in Paris, France
干预措施: Spider flash ECG, high-precision carotid echo-tracking, step test
结局指标
主要结局
cardiovascular disease (CVD)
时间窗: through study completion, an average of 24 years
incident coronary heart disease (CHD), stroke, sudden death, mortality
次要结局
- heart rate parameters and baroreflex sensitivity(4 Years)
- other CVD outcomes(through study completion, an average of 24 years)