Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population. The Paris Prospective Study III
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 10,157
- 试验地点
- 1
- 主要终点
- cardiovascular disease (CVD)
研究概览
简要总结
The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.
详细描述
Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •50-75 years, French speaking, given consent for genetic analysis,
- •written consent for participating in the study
排除标准
- •<50 years and >75 years,
- •no French speaking,
- •current pregnancy,
- •chronic severe disease,
- •disagreement for genetic analysis,
- •step test considered as non possible or non advisable by medical decision.
研究组 & 干预措施
general population
Observational study of 10157 adult men and women from the general population who benefited from a free extensive health check up in Paris, France
干预措施: Spider flash ECG, high-precision carotid echo-tracking, step test (Other)
结局指标
主要结局
cardiovascular disease (CVD)
时间窗: through study completion, an average of 24 years
incident coronary heart disease (CHD), stroke, sudden death, mortality
次要结局
- heart rate parameters and baroreflex sensitivity(4 Years)
- other CVD outcomes(through study completion, an average of 24 years)