Phase I Study of Cilengitide (EMD 121974) in Children With Refractory Brain Tumors
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- MTD of cilengitide
研究概览
简要总结
This phase I trial is studying the side effects and best dose of cilengitide in treating children with recurrent, progressive, or refractory primary CNS tumors. Cilengitide may slow the growth of brain cancer cells by stopping blood flow to the tumor.
详细描述
PRIMARY OBJECTIVES:
I. To describe the acute and dose-limiting toxicities (DLT) and define the maximum tolerated dose (MTD) of cilengitide (EMD 121974) when administered to children and adolescents with refractory primary brain tumors.
SECONDARY OBJECTIVES:
I. To obtain preliminary evidence of biologic activity by determining alterations in tissue perfusion, tumor blood flow and metabolic activity using MR perfusion, PET and MRS and correlating these findings with changes in tumor size by volumetric MRI.
II. To characterize inter- and intra-patient variability in the pharmacokinetics of cilengitide and to estimate cilengitide renal clearance in this patient population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with histological diagnosis of primary CNS tumor and evidence that the tumor is recurrent or progressive and refractory to standard therapy, including histologically benign CNS tumors (e.g. low-grade glioma); clinical and radiographic evidence of a brain stem or optic pathway glioma is required in the absence of histologic diagnosis
- •Karnofsky or Modified Lansky Score ≥ 50%
- •Patients with neurological deficits should have deficits that are stable for ≥ 1 week prior to study entry
- •Chemotherapy: Patients with evidence of recovery from prior therapy; no investigational agent, including biologic agent, within two (2) weeks of study entry; at least six (6) weeks from nitrosourea agent to study entry; at least four (4) weeks from any myelosuppressive therapy to study entry
- •Bone Marrow Transplant: Greater than six (6) months prior to study entry
- •XRT: At least six (6) weeks from prior radiation therapy to study entry; greater than three (3) months from prior craniospinal irradiation (> 24 Gy) or total body irradiation to study entry; greater than two (2) weeks from local palliative irradiation to study entry
- •Anti-convulsants: Patients will be eligible for this study even if they are receiving anti-convulsants
- •Growth factors: Off all colony forming growth factor(s) > one (1) week prior to study entry (G-CSF, GM-CSF, erythropoietin)
- •Corticosteroids: Patients receiving corticosteroids must be receiving a stable dose for ≥ one (1) week prior to study entry
- •ANC > 1,000/μl
- •Platelets > 100,000/μl (transfusion independent)
- •Hemoglobin > 8.0 g/dl (may be transfused)
- •Patients with bone marrow involvement may be eligible
- •Creatinine < 1.5 times normal range for age
- •GFR > 70 ml/min/1.73m^2
- •Total bilirubin ≤ upper limit of normal for age
- •SGPT (ALT) and SGOT (AST) < 2.5 times upper limit of normal
- •Cilengitide was teratogenic when tested in animals; as such, female patients of childbearing potential must have a negative serum or urine pregnancy test prior to study entry; female patients must avoid breast feeding while on study
- •Patients of childbearing potential must be willing to use a medically acceptable form of birth control, which includes abstinence, while being treated on this study
- •Signed informed consent according to institutional guidelines must be obtained prior to patient registration
排除标准
- •Patient must not be receiving any other anticancer or experimental drug therapy, with the exception of corticosteroids
- •Patient must have no uncontrolled infection
- •Patient has no overt renal, hepatic, cardiac or pulmonary disease
研究组 & 干预措施
Treatment (cilengitide)
Patients receive cilengitide (EMD 121974) IV over 1 hour twice weekly. Treatment repeats every 4 weeks for 13 courses in the absence of disease progression or unacceptable toxicity.
Cohorts of 3-6 patients receive escalating doses of cilengitide until the MTD is determined. The MTD is defined as the dose at which 25% of patients are expected to experience dose-limiting toxicity. Once the MTD is determined, 6 additional patients are accrued and treated at that dose level for a total of 12 patients at the MTD.
干预措施: cilengitide (Drug)
Treatment (cilengitide)
Patients receive cilengitide (EMD 121974) IV over 1 hour twice weekly. Treatment repeats every 4 weeks for 13 courses in the absence of disease progression or unacceptable toxicity.
Cohorts of 3-6 patients receive escalating doses of cilengitide until the MTD is determined. The MTD is defined as the dose at which 25% of patients are expected to experience dose-limiting toxicity. Once the MTD is determined, 6 additional patients are accrued and treated at that dose level for a total of 12 patients at the MTD.
干预措施: laboratory biomarker analysis (Other)
结局指标
主要结局
MTD of cilengitide
时间窗: 4 weeks
次要结局
- Response(Up to 3 months)