The Effects of add-on Anti-diabetic Drugs in Type 2 Diabetic Patients

Recruiting

• Conditions: Hyperglycemia

• Registration Number: NCT02885922
• Lead Sponsor: Taichung Veterans General Hospital

Brief Summary

Recently, there are some new classes of anti-diabetic drugs availible in Taiwan. In this study, we will observe the change in inflammation and energy homeostasis in type 2 diabetic outpatient, who receiving a new anti-diabetic drugs.

Detailed Description

Recently, there are some new classes of anti-diabetic drugs availible in Taiwan. However, the effects of these anti-diabetic drugs should be further evaluated. Specially, the effects on inflammation and energy homeostasis are still not well assessed. In this study, we will observe the change in inflammation and energy homeostasis in type 2 diabetic outpatient, who receiving a new anti-diabetic drugs.

Study Timeline

• Study First Submitted: 2016-08-26
• Study First Submitted QC: 2016-08-26
• Study Start: 2016-09
• Study First Posted: 2016-09-01
• Status Verified: 2019-12
• Last Update Submitted: 2020-01-04
• Last Update Posted: 2020-01-07
• Primary Completion: 2024-12
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 6000

Inclusion Criteria

• Type 2 diabetic outpatient

Exclusion Criteria

• Refusal of anti-diabetic drugs
• Preganacy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
HbA1c	3 months

Secondary Outcome Measures

Name	Time	Method
Fasting glucose	3 months
Brain-Derived Neurotrophic Factor (BDNF)	3 months	energy homeostasis
Body-composition	3 months	energy homeostasis
Vascular Cell Adhesion Molecule 1 (VCAM-1)	3 months	inflammation
Ankle-Brachial Index (ABI)	12 months	peripheral artery disease
Hypoglycemia	3 months
Orexin-A	3 months

Trial Locations

Locations (1)

outpatient clinic of the Division of Endocrinology and Metabolism in Taichung Veterans General Hospital; 🇨🇳 Taichung, Taiwan