ULTRASOUND GUIDED ASPIRATION PLUS ANTIBIOTICS VS ANTIBIOTICS IN CHILDREN OF LIVER ABSCESS

Completed

Conditions: Abscess of liver, (2) ICD-10 Condition: K750||Abscess of liver,

Registration Number: CTRI/2018/08/015500

Lead Sponsor: Dept of Health Research Ministry of Health and Family Welfare

Brief Summary: This study is an attempt to compare clinical outcome of two most widely used regimens for management of liver abscess, i.e. percutaneous needle aspiration plus antibiotics and medical management alone. Enrolled patients will be randomized into two groups and treatment will be started. One group will receive antibiotics and aspiration of liver abscess will be carried out within 24-48 hours of admission and after correction of any coagulation abnormalities and initial stabilization of the patient.Another group will receive only antibiotics. Clinical, laboratory and ultrasound parameters will be monitored as per protocol.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 110

Inclusion Criteria

Ultrasound within the preceding seven days suggestive of uncomplicated liver abscess 3-8 cm (for children 1-5 years) or 3-10 cm (for children 5-18 years).

Exclusion Criteria

1.Left lobe liver abscess 2.Caudate lobe liver abscess 3.Ultrasound features suggestive of imminent rupture i.e., less than 1 cm liver tissue around abscess cavity 4.Associated with other surgical conditions acute appendicitis, acute cholecystitisetc 5.Known immune-compromised state 6.Children with signs and symptoms suggestive of liver cell failure.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical cure is defined as:Absence of documented fever, abdominal pain and Ultrasound showing reduction in size of liver abscess.	6 weeks

Secondary Outcome Measures

Name	Time	Method
To compare rate of clinical response:	1.Fever resolution time

Trial Locations

Locations (1): UCMS & GTB Hospital, Delhi
🇮🇳
East, DELHI, India
UCMS & GTB Hospital, Delhi
🇮🇳East, DELHI, India
Dr Manish Narang
Principal investigator
01122692695
manish_2710@yahoo.com