CESAR: Conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure
Completed
- Conditions
- Respiratory tract diseases: Severe acute respiratory failureRespiratorySevere acute respiratory failure
- Registration Number
- ISRCTN47279827
- Lead Sponsor
- Department of Health (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
1. Adult patients (18-65 years in UK)
2. With severe, but potentially reversible respiratory failure. Severe respiratory failure will be defined as a Murray score >3.0, or uncompensated hypercapnoea with a pH <7.20
Exclusion Criteria
1. Duration of high pressure and/or high FiO2 ventilation >7 days
2. Intra-cranial bleeding
3. Any other contra-indication to limited heparinisation
4. Patients who are moribund and have any contra-indication to continuation of active treatment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Death or severe disability at six months. Severe disability will be defined as requiring full time nursing care at home, or continued residence in hospital.
- Secondary Outcome Measures
Name Time Method