Efficacy of nanohydroxyapatite in Periodontal regeneration

Pre-surgical procedures:

Patients fulfilling the inclusion criteria and have willingly given informed consent will be subjected to phase-1 therapy comprising of full-mouth scaling, root planing, and occlusal corrections if required.

The subjects will be monitored for plaque control and tissue response and if found satisfactory will be prepared for surgery. Gingival index and plaque index will be recorded at baseline on the day of surgery. Intraoral radiographs with the grid will be taken by using paralleling technique to record osseous defect depth, Alveolar crest level.

Method:

Following local anesthesia with 2% Lignocaine, using block and infiltration techniques, intra-crevicular incisions will be given to reflect the full thickness mucoperiosteal flaps for defect access and debridement.

The patients will be randomly divided into two study groups by computer alloted method

GROUP-A {Test group}; Intra-bony defects will be filled with injectable nano hydroxyapatite-chitosan scaffold.

GROUP-B {Control group}; Intrabony defects will be filled with nano-hydroxyapatite bone graft.

The surgical flaps will be repositioned and sutured using 4-0 black silk to achieve primary closure.

post-operative instructions will be given.

Post-surgical Evaluation:

Patients will be recalled after 7 days for surgical removal

Recall examinations will be scheduled at 3,6,9 months postoperatively and all the clinical parameters will be recorded

Radiographic parameters(IOPAR with grid) and CBCT will be assessed at baseline and after 9 months

Patients will be monitored periodically for their oral hygiene maintenance.