IRCT20221130056672N4RecruitingPhase 1
Safety and efficacy of injection of Umbilical Cord Blood Serum derived exosomes for skin lesions in patients with chronic psoriasis(Phase ? of clinical trial)
Trial Snapshot
- Phase
- Phase 1
- Status
- Recruiting
- Enrollment
- 30
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 years to 65 years (—)
- Sex
- All
Inclusion Criteria
- •Age older than 18 years
- •Patients with chronic plaque psoriasis for at least 6 months
- •PASI index 3 to 12
- •Lesion intensity 1 to 3 (rating 0 to 5)
- •Lack of proper response to standard treatments including local treatments, light therapy and systemic treatments
- •Not creating new lesions or increasing the size of previous lesions in the last 3 months
- •Skin lesion with BSA higher than 10%
Exclusion Criteria
- •Use of systemic immunosuppressive drugs in the last 4 weeks and topical drugs except emollients in the last 2 weeks
- •Severe underlying disease (liver-kidney and heart failure)
- •Increase of liver enzymes > 3 times normal and creatinine > 2
- •Patients with diabetes mellitus, patients with a history of hepatitis B, C or HIV
- •Pregnant and nursing mothers
- •Patients with immunodeficiency, patients with malignancy, presence of debilitating disease, presence of active infection
Investigators
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