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Clinical Trials/IRCT20221130056672N4
IRCT20221130056672N4RecruitingPhase 1

Safety and efficacy of injection of Umbilical Cord Blood Serum derived exosomes for skin lesions in patients with chronic psoriasis(Phase ? of clinical trial)

Tehran University of Medical Sciences0 sites30 target enrollmentStarted: TBDLast updated:

Trial Snapshot

Phase
Phase 1
Status
Recruiting
Enrollment
30

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Interventional

Eligibility Criteria

Ages
18 years to 65 years (—)
Sex
All

Inclusion Criteria

  • Age older than 18 years
  • Patients with chronic plaque psoriasis for at least 6 months
  • PASI index 3 to 12
  • Lesion intensity 1 to 3 (rating 0 to 5)
  • Lack of proper response to standard treatments including local treatments, light therapy and systemic treatments
  • Not creating new lesions or increasing the size of previous lesions in the last 3 months
  • Skin lesion with BSA higher than 10%

Exclusion Criteria

  • Use of systemic immunosuppressive drugs in the last 4 weeks and topical drugs except emollients in the last 2 weeks
  • Severe underlying disease (liver-kidney and heart failure)
  • Increase of liver enzymes > 3 times normal and creatinine > 2
  • Patients with diabetes mellitus, patients with a history of hepatitis B, C or HIV
  • Pregnant and nursing mothers
  • Patients with immunodeficiency, patients with malignancy, presence of debilitating disease, presence of active infection

Investigators

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