The Effect of Non Invasive Brain Stimulation on Impulsivity in Borderline Personality Disorder

Not Applicable

Completed

• Conditions: Borderline Personality Disorder
• Interventions: Device: NeuroConn

• Registration Number: NCT05453032
• Lead Sponsor: Ciusss de L'Est de l'Île de Montréal

Brief Summary

A pilot study to examine the effects of Non-Invasive Brain stimulation on impulsive behaviour in patients diagnosed with Borderline Personality Disorder. patients who received the neurostimulation sessions will be enrolled in short term psychotherapy (3-month)

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-10
• Study First Submitted: 2022-03-29
• Primary Completion: 2022-03-30
• Study First Submitted QC: 2022-07-06
• Study First Posted: 2022-07-12
• Study Completion: 2022-07-20
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-11
• Last Update Posted: 2023-02-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

Not provided

Exclusion Criteria

• material Metal in the brain
• History of seizure or epilepsy
• severe scalp irritation or eczema
• recent scares, cut wounds, tattoo on the scalp
• severe substance use disorder
• clinical diagnosis of severe mood disorders o
• Active psychotic episode
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patients with BPD assigned to the trial of 10 active tDCS sessions followed by psychotherapy	NeuroConn	Patients diagnosed with Borderline Personality disorder and BPDSI score is \> or = 17 will be assigned for active tDCS session (NeuroConn, Germany) candidates will have 20-minute session per day for 10 weekdays in 2 weeks. Then they will attend short term psychotherapy session for 3 months.

Primary Outcome Measures

Name	Time	Method
The effect of NIBS on impulsivity (UPPS- Behavioral Impulsive scale)	2-week stimulation session	Patients with BPD will complete UPPS impulsive behavioral scale, a self reported questionnaire, before the first tDCS session and after they complete the 10 sessions of tDCS sessions. this questionnaire consists of 45 questions with 4 likert scale range for each question. The questionnaire is divided into 4 subscales: Urgency, lack of premeditation, lack of perseverance, sensation seeking.

Secondary Outcome Measures

Name	Time	Method
The effect of tDCS on BPD severity overall ( Borderline Personality Disorder Severity Index: BPDSI)	3 months	The BPD patients who attend the tDCS sessions and the short-term psychotherapy will be evaluated by one psychiatric with a semi-structured interview evaluation, Borderline Personality disorder Severity Index (BPDSI)
The Effect of tDCS on Risk taking ( an impulsive behavior dimension)	2 weeks	a computerized measure of risk taking behavior. Each participant will have a set of 30 balloons with temporary and permanent bank. The possibility of balloon explosion increased each time the participant inflate ( click on the balloon) while the amount of money increased by 0.5 euro with each inflation. the participant could more the earned money from inflation anytime before unexpected balloon explosion to the permanent bank. The total number of the pumps will determine the probability of risk taking behavior
the effect of tDCS on depressive symptoms in BPD (Montgomery-Asberg Depression Rating Scale (MADRS))	2 weeks	A self reported questionnaire that assess the depressive symptoms in the last 3 days. it consists of 9 questions with 3 likert score range ; each question examines different aspect of depression.

Trial Locations

Locations (1)

Centre Recherche_ Institut Univesitaire de Santé Mentale à Montréal; 🇨🇦 Montréal, Quebec, Canada