Perifollicular Nerves in Alopecia Areata: Response to Topical Capsaicin
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Topical capsaicin will quantitatively decrease the amount of Substance P in the scalp of AA patients.
研究概览
简要总结
It has been postulated that Alopecia Areata (AA) is, at least in part, a neurologically mediated disease. Research supporting this theory includes the finding that nerves surrounding the hair follicles are collapsed. We want to take this research a step further and show that not only are these perifollicular nerves collapsed, but that their function is also impaired.
详细描述
To assess the function of perifollicular scalp nerves in AA we will look at the response of these nerves to the topical medication capsaicin. Under normal circumstances topical capsaicin is known to target nerves in the peripheral nervous system causing short-term release of the neuropeptide Substance P (SP) as well as long-term transient depletion of SP. We expect the AA patients will respond abnormally to topical capsaicin treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Must have alopecia totalis or universalis.
- •Be in good health.
- •Not be taking any medications including topical medications
- •Be 18 years or older.
- •Be willing to apply study medication or vehicle as directed, comply with instructions and commit to follow-up visits.
- •Not have had hair chemically treated (including colored hair, permed hair, etc) within the month prior to the study.
排除标准
- •Absence of extensive alopecia areata.
- •People not in good health.
- •People taking medications.
- •Allergies to capsaicin.
- •Presence of irritated or visibly inflamed scalp.
- •Having had hair chemically treated (including colored hair, permed hair, etc.) within the month prior to study.
结局指标
主要结局
Topical capsaicin will quantitatively decrease the amount of Substance P in the scalp of AA patients.
次要结局
- The scalps of AA patients may be less sensitive to stimuli.