GENSARC 2008 : Medical Economic Evaluation of the Molecular Detection by FISH (Fluorescent in Situ Hybridization) and by PCR (Polymerase Chain Reaction) of Sarcomas Specific Translocations and Amplifications .

Completed

• Conditions: Sarcoma

• Registration Number: NCT00847691
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

The clinical and histological diagnosis of sarcomas is often very difficult. The identification of chromosomal and molecular anomalies, such as amplifications, deletions or fusion genes is a powerful help for establishing a correct diagnosis of sarcomas and their benign counterparts. However, the cost of the cytogenetic and molecular techniques for the detection of these alterations is often a limitation to their use. The aim of our study is to evaluate the direct cost of the molecular techniques in comparison to the cost that would be generated by an appropriate therapy and care management of the patient in case of an erroneous diagnosis.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-02
• Study First Submitted: 2009-02-18
• Study First Submitted QC: 2009-02-18
• Study First Posted: 2009-02-19
• Study Start: 2009-03
• Primary Completion: 2012-03
• Study Completion: 2012-07
• Last Update Submitted: 2012-12-17
• Last Update Posted: 2012-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 350

Inclusion Criteria

• patients with biopsy or excision of sarcoma (suspected or diagnosed)
• sampling reviewed by pathologists
• frozen sampling
• clinical data available

Exclusion Criteria

• opposition of patient

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (8)

Laboratoire de Biochimie et Biologie Moléculaire, CHRU de Lille; 🇫🇷 Lille, France

Laboratoire de Génétique des Tumeurs Solides; 🇫🇷 Nice, France

Unité de Biologie Moléculaire, CHU de Hautepierre; 🇫🇷 Strasbourg, France

Département de biologie et de pathologie médicales, Institut Gustave roussy; 🇫🇷 Villejuif, France

Département d'Anantomie et de Cytologie Pathologie, Centre Léon Berard; 🇫🇷 Lyon, France

Departement de Pathologie de l'Institut Bergonié; 🇫🇷 Bordeaux, France

Institut Curie; 🇫🇷 Paris Cedex 5, France

Service d'Anatomo-Pathologie, Centre Paul Strauss; 🇫🇷 Strasbourg, France