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临床试验/CTRI/2023/07/055410
CTRI/2023/07/055410尚未招募3 期

A Comparative Study To Evaluate The Efficacy Of Rajanyadi Seka And Lodhra Seka With Bibhitaki Ghrita Internally In The Management Of Shushkakshipaaka W S R Dry Eye Syndrome

Dr Shruti D Gangannavar1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2023年7月28日最近更新:

试验速览

阶段
3 期
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
schirmers test

研究概览

简要总结

Sushkakshipaka is one of the Vataja(Sushruta)1 /Vata-pittaja(Vagbhata) Sarvagata, Sadhya

Netrarogas. Features of Shushkakshipaka includes hard and dry eye lids, found drooping; blurred

vision and difficulty to open the eyes with foreign body sensation2 . The Lakshanas of

Shushkakshipaka can be equated with the signs and symptoms of Dry Eye Syndrome. Dry Eye is a

disorder of the tear film due to tear deficiency or excessive tear evaporation which causes damage

to the inter palpebral ocular surface and is associated with symptoms of ocular discomfort. The

climate of tropical India and globalization along with the sprout of millions of IT professionals are

making Dry Eye Syndrome, a fast growing disease, as all these leads to increased tear evaporation

(due to dry wind, air conditioning, decreased blink reflex etc.) along with other causes like aqueous

tear deficiency, mucin deficiency, lipid deficiency, impaired lid function, irregular corneal surface

etc.The prevalence of DES in India is higher than the global prevalence and ranges from 18.4% to

54.3%. To explore effective solution in Ayurveda is the need of the hour as is no complete cure for

Dry eyes in contemporary medicines at present.Some of the treatment modalities which have been

tried with variable results include supplementation with tear substitutes, topical cyclosporine,

mucolytic, topical retinoid, preservation of existing tears etc. along with correction of lid

abnormalities, which are not long lasting and thus long-term usage is recommended. The treatment

modalities that are told in classics for this are Ghritapaana, Tarpana, Seka, Aschotana, Anjana etc.

which are known to increase the stability of tear film and give relief from the symptoms of

Shushkakshipaka. Hence this study is taken to overcome the challenges in treating the dry eye syndrome.

研究设计

研究类型
Interventional
分配方式
Not Applicable
盲法
Not Applicable

入排标准

年龄范围
18.00 Year(s) 至 60.00 Year(s)(—)

入选标准

  • All The Patients Presenting The Signs And Symptoms Of The Sushkakshipaka Will BE Taken For The Study Clinical Trails Irrespective Of Gender Caste Religion Socio Economic Status.

排除标准

  • 1 Injry To Eyes 2 Systemic Disorders Like Rheumatiod Arthritis SLE Sjogrens Syndrome 3 Congenital Alacramia Associated With Any Inflamatory Conditions And 4 Infective Other Conditions Like Glucoma.

结局指标

主要结局

schirmers test

时间窗: 65 Days

Tearfilm Break Up Time

时间窗: 65 Days

次要结局

  • Assessed using self generated scoring(1.Feeling Dirt In The Eyes)

研究者

发起方
Dr Shruti D Gangannavar
申办方类型
Other [self]

研究点 (1)

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