Transcranial Direct-Current Stimulation in Childhood Dystonia

Phase 2

• Conditions: Childhood Onset Dystonias
• Interventions: Device: TDCS (Transcranial Direct-current Stimulation); Device: sham TDCS (Transcranial Direct-current Stimulation)

• Registration Number: NCT01460771
• Lead Sponsor: University of Southern California

Brief Summary

The investigators hypothesize that transcranial direct current stimulation over the motor cortex will reduce muscle overflow and improve hand function in children with primary or secondary dystonia.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2011-09-27
• Study First Submitted QC: 2011-10-26
• Study First Posted: 2011-10-27
• Status Verified: 2014-05
• Last Update Submitted: 2014-05-20
• Last Update Posted: 2014-05-22
• Primary Completion: 2017-09
• Study Completion: 2017-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• dystonia affecting one or both hands
• age 4 to 21 years

Exclusion Criteria

• metal implants in the head
• inability to cooperate with instructions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Treatment	TDCS (Transcranial Direct-current Stimulation)	Active Transcranial Direct Current Stimulation (TDCS) at 1mA or highest tolerated current
sham	sham TDCS (Transcranial Direct-current Stimulation)	inactive Transcranial Direct current stimulation (TDCS) at 0mA

Primary Outcome Measures

Name	Time	Method
Hand muscle overflow	10 minutes post- transcranial Direct-current Stimulation (TDCS)	surface EMG measure of overflow into muscles during attempted relaxation.

Trial Locations

Locations (1)

University of Southern California; 🇺🇸 Los Angeles, California, United States