Treatment of bone diseases with porous ceramics integrated with autologous bone marrow derived mesenchymal cells
Phase 1
Completed
- Conditions
- massive bone defects, fracture non-union
- Registration Number
- JPRN-UMIN000000649
- Lead Sponsor
- Osaka University Graduate School of Medicine, Department of Orthopedics
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Not provided
Exclusion Criteria
Active local infection Serious complications including malignancies Diabetes Dialysis for renal failure Under the influence of steroids or other drugs that affect bone metabolism Infectious diseases (HIV, HBV, HCV, HTLV, syphilis) Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie mesenchymal stem cell integration with porous ceramics in bone regeneration?
How does porous ceramic with autologous mesenchymal cells compare to standard bone grafting techniques in non-union fracture repair?
Which biomarkers correlate with successful osteogenesis in autologous MSC-ceramic composite therapies for massive bone defects?
What are the long-term safety profiles of MSC-seeded porous ceramics in clinical trials for orthopedic bone diseases?
Are there combination therapies involving MSC-ceramic constructs and BMP signaling modulators for enhanced bone defect healing?