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临床试验/CTRI/2023/06/053679
CTRI/2023/06/053679已完成不适用

Success rate of nasogastric tube insertion in anaesthetised, intubated, adult patients: A comparison between endotracheal tube cuff inflated and deflated states

Department of Anaesthesiology1 个研究点 分布在 1 个国家目标入组 244 人开始时间: 2023年1月7日最近更新:

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
244
试验地点
1
主要终点
Proportion of patients in whom successful nasogastric tube insertion will be possible in first attempt.

研究概览

简要总结

Successful placement of nasogastric tube (NGT) in anaesthetised patients in operating room under General  Anaesthesia appears to be challenging one compared with its insertion in awake patients owing to lack of patients cooperation in the former. In the study a comparison was done between the nasogastric tube insertion with endotracheal tube cuff inflated state and that with endotracheal cuff deflated state. Comparison was done in terms of success in the first attempt, procedure time and incidence of adverse events.

In other words, the present study was conducted to compare the first-attempt success rate (primary outcome) of blind NGT insertion in neutral position between patients with ETT cuff inflated state and those with ETT deflated state; using “throat pack in-situ†as additional safety measure. Data from all 244 patients were available for analysis. Patients of both the two groups were comparable regarding their demographic parameters.

NGT insertion with ETT cuff deflated was feasible in a considerably greater number of patients compared with those where ETT cuff was kept inflated. In the current study, NGT insertion was possible in considerably more proportion of patients with the ETT cuff at deflated state compared with cuff at inflated state (approximated, 85% versus 55%, respectively). NGT placement with ETT cuff deflated state achieved about 30% more success rate.

The procedure time for NGT placement was considerably longer with ETT cuff inflated state compared to ETT cuff deflated state (38.1 versus 16.8 seconds, respectively.

In the present study, quicker placement of NGT was possible with the ETT cuff at deflated state than inflated state (approximated, 17 seconds versus 38 seconds, respectively). Thus, ETT cuff deflated state yielded about 20 seconds quicker placement of NGT.

Mean arterial pressure (MAP) and heart rate (HR) were noted at different time points during the procedure: baseline, before NGT insertion, and after NGT insertion. MAP and HR were found to be comparable at all observed time-points between the inflated cuff and deflated cuff groups. In the present study, heart rate and MAP were found comparable at all points of observations between the two groups. This translates into fact that the process of tracheal cuff deflation and re-inflation for a brief period had produced a non-significant hemodynamic response.

Although higher adverse events were observed with ETT cuff inflated state, the difference between the two groups was not significant when analyzed.

Limitations

In spite of every sincere effort the present study has some lacunae. This was a single-center study. Auscultation method was used for confirmation of NGT instead of more robust method such as ultrasonography, pH paper or the gold standard- the X-ray, owing to limited resource.  The study was carried out in a tertiary care hospital, so hospital bias cannot be ruled out. Further research could explore additional factors across the larger and more diverse patient groups.

CONCLUSION

Endotracheal cuff significantly affects the success rate of nasogastric tube insertion. The endotracheal tube cuff deflation-assisted technique improved the chances of successful nasogastric tube placement. It is also associated with reduced adverse events such as bleeding by avoiding multiple attempts.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
Participant Blinded

入排标准

年龄范围
18.00 Year(s) 至 90.00 Year(s)(—)
性别
All

入选标准

  • Adult above 18 years patients undergoing elective Abdominal surgeries that require intra-operative nasogastric tube insertion.

排除标准

  • 1.Anatomical/structural abnormalities such as gross deviated nasal septum, abnormality involving lips and palate.
  • 2.Patients with oral, nasal pharyngeal , oesophageal mass.
  • 3.Patients with significant injuries involving head neck.

结局指标

主要结局

Proportion of patients in whom successful nasogastric tube insertion will be possible in first attempt.

时间窗: Successful insertion of Nasogastric tube in first attempt. more than one attempt will be considered as failure

次要结局

  • 1.Time taken for Successful insertion of nasogastric tube.it is also called procedure time.(2.Adverse events during the procedure like tube kinking, coiling etc.)

研究者

发起方
Department of Anaesthesiology
申办方类型
Government medical college

研究点 (1)

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