The long-term impact on deaths and cost-effectiveness of screening for ovarian cancer using a blood test and ultrasound

Not Applicable

• Conditions: Tubo-ovarian cancer; Cancer; Ovarian cancer

• Registration Number: ISRCTN22488978
• Lead Sponsor: niversity College London (UK)

Brief Summary

2006 Results article in https://www.ncbi.nlm.nih.gov/pubmed/16827831 results 2007 Results article in https://www.ncbi.nlm.nih.gov/pubmed/17237735 results 2008 Results article in https://www.ncbi.nlm.nih.gov/pubmed/19008269 results 2009 Results article in https://www.ncbi.nlm.nih.gov/pubmed/19282241 results 2010 Results article in https://www.ncbi.nlm.nih.gov/pubmed/20648018 results 2011 Results article in https://www.ncbi.nlm.nih.gov/pubmed/21147030 results 2011 Results article in https://www.ncbi.nlm.nih.gov/pubmed/21362184 results 2011 Results article in https://www.ncbi.nlm.nih.gov/pubmed/22086897 results 2012 Results article in https://www.ncbi.nlm.nih.gov/pubmed/22008610 results 2012 Results article in https://www.ncbi.nlm.nih.gov/pubmed/22199143 results 2012 Results article in https://www.ncbi.nlm.nih.gov/pubmed/22596242 results 2012 Results article in https://www.ncbi.nlm.nih.gov/pubmed/22911637 results 2012 Results article in https://www.ncbi.nlm.nih.gov/pubmed/23084519 results 2013 Results article in https://www.ncbi.nlm.nih.gov/pubmed/22791597 results 2013 Results article in https://www.ncbi.nlm.nih.gov/pubmed/23169294 results 2013 Results article in https://www.ncbi.nlm.nih.gov/pubmed/23652307 results 2013 Results article in https://www.ncbi.nlm.nih.gov/pubmed/23456790 results 2013 Results article in https://www.ncbi.nlm.nih.gov/pubmed/24129231 results 2014 Results article in https://www.ncbi.nlm.nih.gov/pubmed/24589827 results 2014 Results article in https://www.ncbi.nlm.nih.gov/pubmed/24122770 results 2014 Results article in https://www.ncbi.nlm.nih.gov/pubmed/24879829 results 2014 Results article in https://www.ncbi.nlm.nih.gov/pubmed/25067956 results 2014 Results article in https://www.ncbi.nlm.nih.gov/pubmed/24865441 results 2014 Results article in https://www.ncbi.nlm.nih.gov/pubmed/25252818 results 2014 Results article in https://www.ncbi.nlm.nih.gov/pubmed/25290619 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/25316052 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/24938522 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/25848938 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/26819954 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/25290539 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/25964255 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/25597499 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/25304359 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/26035703 results 2015 Results article in https://www.ncbi.nlm.nih.gov/pubmed/26222482 results 2016 Results article in https://www.ncbi.nlm.nih.gov/pubmed/26573079 results 2016 Results article in https://www.ncbi.nlm.nih.gov/pubmed/26095052 results 2016 Results article in https://www.ncbi.nlm.nih.gov/pubmed/26707054 results 2016 Results article in https://www.ncbi.nlm.nih.gov/pubmed/26573598 results 2016 Results article in https://www.ncbi.nlm.nih.gov/pubmed/27091764 results 2016 Results article in https://www.ncbi.nlm.nih.gov/pubmed/26815306 results 2016 Results article in https://www.ncbi.nlm.nih.gov/pubmed/27353822 results 2016 Results article in https://www.ncbi.nlm.nih.gov/pubmed/27829038 results 2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/27903971 results 2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/28264823 results 2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/28324886 results 2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/28326899 results 2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/28659136 results 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29587697 results 2020 Results article in https://www.ncbi.nlm.nih.gov/pubmed/32293289 results (added 16/04/2020) 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/31290761/ results (added 22/07/2020) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33494753/ results (added 27/01/2021) 2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/33648562/ update (added 03/03/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33670571/ results on ultrasound strategy performance (added 08/03/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33991479/ Long term follow up results (added 13/08/2021) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37657461/ Exploratory analysis (added 04/09/2023) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37980767/ Ovarian cancer symptoms in pre-clinical invasive epithelial ovarian cancer (added 20/11/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2000-04-06
• Last Update Posted: 4 December 2023
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: Female
• Target Recruitment: 202638

Inclusion Criteria

1. Aged 50 - 74 years
2. Postmenopausal: either
2.1. Greater than 12 months amenorrhoea following a natural menopause or hysterectomy, or
2.2. Greater than 12 months of hormone replacement therapy (HRT) commenced for menopausal symptoms

Exclusion Criteria

1. History of bilateral oophorectomy
2. Currently active non-ovarian malignancy. Women who have a past history of malignancy will only be eligible if:
2.1. They have no documented persistent or recurrent disease, and
2.2. They have not received treatment for more than 12 months
3. Women who have had an ovarian malignancy in the past
4. Women at high risk of ovarian cancer due to familial predisposition as defined by the eligibility criteria for the UK Familial Ovarian Cancer Screening Study (UKFOCSS)
5. Women participating in other ovarian screening trials

Study & Design

• Study Type: Interventional
• Study Design: Not specified