Influence of Factor XIII Activity on the Outcome of Gastrointestinal Bleedings
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 97
- 试验地点
- 1
- 主要终点
- Red cell concentrates
研究概览
简要总结
The aim of this retrospective study is to investigate the relationship between factor XIII activity and the outcome of gastrointestinal bleedings. Since factor XIII is of great importance in haemostasis and plays a key role in stabilizing the fibrin clot, it can be assumed that a deficiency of factor XIII leads to an unfavorable course of gastrointestinal bleedings. Our hypothesis is that early detection of such a deficiency can prevent a more severe course and that substitution of factor XIII contributes to faster cessation of bleeding, improves patient outcome and reduces the number of red cell concentrates required.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age over 18 years
- •Confirmed diagnosis of gastrointestinal bleeding
- •Assessment of factor XIII activity during the gastrointestinal bleeding episode
排除标准
- •Age under 18 years
- •Diagnosis of hemophilia A or B or other congenital coagulation disorders
研究组 & 干预措施
Reduced factor XIII activity
Patients with GI bleeding and reduced factor XIII activity
干预措施: Factor XIII Injection (Drug)
结局指标
主要结局
Red cell concentrates
时间窗: 1 year
Number of red cell concentrates transfused during the hospital stay caused by the gastrointestinal bleeding episode
次要结局
- Mortality(1 year)
- Hospitalization(1 year)
- Interventions(1 year)