Periodic Limb Movement and Genetic Generalized Epilepsy
- Conditions
- Epilepsy Generalized Idiopathic Not Intractable
- Registration Number
- NCT03587506
- Lead Sponsor
- University of Alexandria
- Brief Summary
The study aimed to study the correlation between periodic limb movement occurring during sleep and the different parameters of genetic generalized epilepsy
- Detailed Description
Although periodic limb movements are prevalent among patients with epilepsy, the exact relationship between these movements and epilepsy remains elusive. Objective: The aim of this work was to study the periodic limb movements among patients with genetic generalized epilepsy in relation to different clinical characteristics and seizure recurrence. Methods: Sixty individuals participated in this study: thirty of them were newly diagnosed with genetic generalized epilepsy and thirty were healthy individuals. Sleep quality was assessed using the Pittsburgh Sleep Quality Index questionnaire, and a standard polysomnographic study was conducted to all subjects. All patients then received sodium valproate in therapeutic doses and were followed up for six months. Electroencephalogram (EEG) was done after the follow-up period and seizure recurrence was assessed. Accordingly, patients were classified into three groups according to clinical seizure recurrence and follow-up EEG findings.
Periodic limb movement index and frequency were compared among the patients' groups and were correlated with different clinical characteristics.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Newly diagnosed with genetic generalized epilepsy according to the ILAE 2010 criteria
- did not previously receive AEDs.
- The clinical seizures were either eyewitnessed by physicians or video-recorded to ensure they were true epileptic seizures.
- At least two unprovoked seizures occurring >24 hours apart
- Patients with pre-existing psychiatric illnesses
- Patients with seizures due to toxic or metabolic causes (including glucose disturbance, uremia, and electrolytes disturbance), infections, or structural causes (such as neoplasms)
- Patients using hypnotic drugs
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Seizure recurrence 6 months Clinical major or minor seizure, and electrical seizure
- Secondary Outcome Measures
Name Time Method