Impact of Bulletproof Coffee on Metabolism, Inflammation and Cognitive Function
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Plasma triglycerides
研究概览
简要总结
This study will determine whether acute ingestion of a high fat "Bulletproof Coffee" will lead to changes in plasma triglycerides, immune cell function, as well as cognitive function when compared to a black coffee.
详细描述
In a randomized crossover design, participants will consume a single bulletproof coffee or a single black coffee separated by ~7 days. Each visit commences in the morning after an overnight fast of 10-12 hours, with no exercise the day prior, no coffee consumption the morning of testing, and completion of a food log for dietary duplication prior to visit 2. A fasting blood draw is obtained and cognitive function tests administered, along with questionnaires to assess gastrointestinal distress, arousal, and hunger/fullness before coffee consumption. Following this, one of the coffee beverages is consumed (randomized to each visit). Cognitive testing and questionnaires are completed at 60 minutes after finishing the coffee, another blood draw at 90 minutes, and then cognitive testing, questionnaires and a final blood draw 180 minutes after consuming the coffee. This procedure is repeated during their second experimental visit, in which they consume the remaining coffee based on their randomization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Must be over the age of 18
- •Must drink between 1-4 cups of coffee per day (on average)
- •Must be able to tolerate lactose and dairy products
- •Have not been sick for the past 3 weeks (immune function)
- •Non smoker
- •Must be able to fast for 10-12 hours
排除标准
- •If you are required to take corticosteroids (immune function)
- •Cannot understand or speak English
- •Individual has an auto-immune disease and requires medication
- •Individual is following a ketogenic diet
- •Individual has allergy or sensitivity to dairy, coffee or caffeine or coconut oil
- •Individual has hypertension
结局指标
主要结局
Plasma triglycerides
时间窗: Change over 3 hours following beverage consumption
Circulating triglycerides measured in mmol/L
次要结局
- Immune Cell Activation(Change over 3 hours following beverage consumption)
- Cognitive function(Change over 3 hours following beverage consumption)
研究者
Jonathan Little
Associate Professor
University of British Columbia