Acute High Fat Bulletproof Coffee vs Black Coffee on Metabolism, Inflammation and Cognitive Function in Healthy Adults

Not Applicable

• Conditions: Cognitive Function; Inflammatory Response; Leukocytosis; Triglycerides
• Interventions: Dietary Supplement: High-fat coffee; Dietary Supplement: Black coffee

• Registration Number: NCT04307979
• Lead Sponsor: University of British Columbia

Brief Summary

This study will determine whether acute ingestion of a high fat "Bulletproof Coffee" will lead to changes in plasma triglycerides, immune cell function, as well as cognitive function when compared to a black coffee.

Detailed Description

In a randomized crossover design, participants will consume a single bulletproof coffee or a single black coffee separated by \~7 days. Each visit commences in the morning after an overnight fast of 10-12 hours, with no exercise the day prior, no coffee consumption the morning of testing, and completion of a food log for dietary duplication prior to visit 2. A fasting blood draw is obtained and cognitive function tests administered, along with questionnaires to assess gastrointestinal distress, arousal, and hunger/fullness before coffee consumption. Following this, one of the coffee beverages is consumed (randomized to each visit). Cognitive testing and questionnaires are completed at 60 minutes after finishing the coffee, another blood draw at 90 minutes, and then cognitive testing, questionnaires and a final blood draw 180 minutes after consuming the coffee. This procedure is repeated during their second experimental visit, in which they consume the remaining coffee based on their randomization.

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2020-01-01
• Study First Submitted: 2020-02-04
• Status Verified: 2020-03
• Study First Submitted QC: 2020-03-11
• Last Update Submitted: 2020-03-11
• Study First Posted: 2020-03-13
• Last Update Posted: 2020-03-13
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Must be over the age of 18
• Must drink between 1-4 cups of coffee per day (on average)
• Must be able to tolerate lactose and dairy products
• Have not been sick for the past 3 weeks (immune function)
• Non smoker
• Must be able to fast for 10-12 hours

Read More

Exclusion Criteria

• If you are required to take corticosteroids (immune function)
• Cannot understand or speak English
• Individual has an auto-immune disease and requires medication
• Individual is following a ketogenic diet
• Individual has allergy or sensitivity to dairy, coffee or caffeine or coconut oil
• Individual has hypertension

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Bulletproof Coffee	High-fat coffee	A black coffee (bullet proof coffee keurig pod) with 29 grams of added fat (1 tablespoon bullet proof brain octane medium chain triglyceride oil, and 1 tablespoon bullet proof grass fed ghee) blended for 20 seconds with butter scent that is added to the lid.
Bulletproof Coffee	Black coffee	A black coffee (bullet proof coffee keurig pod) with 29 grams of added fat (1 tablespoon bullet proof brain octane medium chain triglyceride oil, and 1 tablespoon bullet proof grass fed ghee) blended for 20 seconds with butter scent that is added to the lid.
Black Coffee	Black coffee	Black coffee that is blended for 20 seconds with butter scent added to the top of the lid.
Black Coffee	High-fat coffee	Black coffee that is blended for 20 seconds with butter scent added to the top of the lid.

Primary Outcome Measures

Name	Time	Method
Plasma triglycerides	Change over 3 hours following beverage consumption	Circulating triglycerides measured in mmol/L

Secondary Outcome Measures

Name	Time	Method
Immune Cell Activation	Change over 3 hours following beverage consumption	Assessment of activation markers on monocytes and neutrophils measured as median fluorescence intensity by flow cytometry.
Cognitive function	Change over 3 hours following beverage consumption	Measures of cognitive function including Stroop test, digit substitution, and reaction time measured via computerized test battery.

Trial Locations

Locations (1)

University of British Columbia, Okanagan.; 🇨🇦 Kelowna, British Columbia, Canada