Topical Agents Containing Magnesium Sulfate & Wound Healing in the Rat Model

Early Phase 1

• Conditions: Wound Heal
• Interventions: Other: Experimental drug 2; Other: Experimental drug 1; Other: placebo comparator; Other: sham comparator; Drug: Centella asiatica

• Registration Number: NCT04886882
• Lead Sponsor: Başakşehir Çam & Sakura City Hospital

Brief Summary

An experimental study examining wound healing in 5 different groups on 30 rats.

Detailed Description

Magnesium topically increases collagen synthesis and angiogenesis, providing faster and higher quality wound healing. In addition, with its analgesic effect, it will also eliminate the pain sensation caused by the wound and increase the quality of life of the patient whose skin integrity is impaired.

Study Timeline

• Study Start: 2021-03-22
• Status Verified: 2021-04
• Study First Submitted: 2021-04-13
• Study First Submitted QC: 2021-05-10
• Last Update Submitted: 2021-05-10
• Study First Posted: 2021-05-14
• Last Update Posted: 2021-05-14
• Primary Completion: 2021-06-01
• Study Completion: 2021-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• healthy rats between ages of 8- 12 weeks

Exclusion Criteria

• weight loss of more than 15% of body weight

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group %10 MgSO4	Experimental drug 2	Cream containing 10% MgSO4 will be applied twice a day to 6 female rats.
Group %1 mgso4	Experimental drug 1	Cream containing 1% MgSO4 will be applied twice a day to 6 female rats.
Group placebo	placebo comparator	Isotonic solution will be administered daily to 6 female rats.
Group sham	sham comparator	Base cream to be applied twice a day to 6 female rats.
Group positive control	Centella asiatica	Cream containing centella asiatica will be applied twice a day to 6 female rats.

Primary Outcome Measures

Name	Time	Method
7th day evaluation	7th day	Histopathological evaluation of wound healing comparing with the rate of vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta) and hydroxyproline at immunohistochemical staining with biopsy on the 7th day.

Secondary Outcome Measures

Name	Time	Method
15th day evaluation	15th day	Histopathological evaluation of wound healing comparing with the rate of VEGF, TGF-beta and hydroxyproline at immunohistochemical staining with biopsy on the 15th day.

Trial Locations

Locations (1)

Başakşehir Çam Ve Sakura Hospital; 🇹🇷 Istanbul, Turkey