Effect of 3-week AT-1 receptor blockade on insulin resistance in relation to endocrine activity of adipose tissue in patients with insulin resistance - Micardis and insulin resistance
- Conditions
- Metabolic syndrome with impaired glucose homeostasis nad prehypertension
- Registration Number
- EUCTR2006-000490-29-CZ
- Lead Sponsor
- Insitute for Clinical and Experimental Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Male
- Target Recruitment
- 15
Presence of metabolic syndrome according to NCEP AT III and impaired glucose homeostasis
Hypertension, pharmacologically untreated
Age 30 - 65 years
BMI 25 - 35 kg/m2
Patients must be able to complete all planned visits and to finish the study safely according to investigators opinion
Written informed consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Diabetes mellitus
Important internal disease cardiovascular, tumorous or autoimmune
Thyreopathy or other important endocrine disease
Drug or alcohol dependence
Known hypersensitivity to IMP or to substances of similar chemical structure
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To evaluate the effect of telmisartan on insulin resistance measured by hyperinsulinaemic euglycaemic clamp;Secondary Objective: To monitor expressions of selected adipokines in subcutaneous adipose tissue;Primary end point(s): Insulin effect in glucose metabolism, tested by hyperinsulinaemic euglycaemic clamp
- Secondary Outcome Measures
Name Time Method