STroke imAging Prevention and Treatment (START): PrePARE Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke

Not Applicable

Completed

• Conditions: Stroke; Depression; Cognition; Stroke - Ischaemic; Physical Medicine / Rehabilitation - Occupational therapy; Mental Health - Depression

• Registration Number: ACTRN12610000987066
• Lead Sponsor: ational Stroke Research Institute (NSRI)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-11-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Patients presenting with ischaemic stroke.
2. Patient, family member or legally responsible person depending on local ethics requirements has given informed consent for participation in the START_PrePARE study
3. Patient’s age is > 18 years.

Exclusion Criteria

1. Patients who are non-English speaking
2. Contraindication to MR imaging on 3Tesla scanner.
3. Pre-stroke MRS score of greater or equal to 2 (indicating previous disability)
4. Any terminal illness such that the patient would not be expected to survive more than 1 year.
5. Pregnant women (clinically evident)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Functional and structural changes in the brain: i.e cortical thickness, fibre tract connection and functional resting-state connections.[3 and 12 months];Depression (Montgomery-Asberg Depression Rating Scale with non-verbal supports)[3 and 12 months];Functional status: Functional Independence (mRS), Cognition (MoCA, MMSE, Trails-B, Digit span, Shape Cancellation Task, RCPM, Stroop test), and Sensorimotor (Action Research Arm Test, Tactile Discrimination Test, Timed up and go test)[3 and 12 months]

Secondary Outcome Measures

Name	Time	Method
Participation (Activity Card Sort)[3 and 12 months];Quality of life (Stroke Impact Scale)[3 and 12 months];Mortality and recurrent stroke[3 and 12 months]