Evaluation of Digit Tip and Split Skin Donor Site Transcriptome

Active, not recruiting

• Conditions: Digit Tip Wound; Split Skin Donor Site
• Interventions: Other: Digit Tip Wound; Other: Split Skin Donor Site Wound

• Registration Number: NCT05991765
• Lead Sponsor: University Hospital Schleswig-Holstein

Brief Summary

Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.

Detailed Description

Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.

Study Timeline

• Study Start: 2021-06-01
• Primary Completion: 2022-04-30
• Status Verified: 2023-08
• Study First Submitted: 2023-08-07
• Study First Submitted QC: 2023-08-07
• Last Update Submitted: 2023-08-07
• Study First Posted: 2023-08-15
• Last Update Posted: 2023-08-15
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

1. Digit Tip Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Digit Tip Wound
2. Split Skin Donor Site Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Split Skin Donor Site Wound

Exclusion Criteria

• Inflammation
• Borderline
• Infectious Disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Digit Tip Wound	Digit Tip Wound	Experimental Wound Exudate from Digit Tip Wounds
Split Skin Donor Site Wound	Split Skin Donor Site Wound	Active Comparator Wound Exudate from Split Skin Donor Site Wound

Primary Outcome Measures

Name	Time	Method
Differences in RNA-Expression pattern	5 Weeks	Differences in RNA-Expression pattern between Digit Tip Wound and Split Skin Donor Site Wound

Trial Locations

Locations (1)

University of Schleswig-Holstein; 🇩🇪 Lübeck, Schleswig-Holstein, Germany