Evaluation of Digit Tip and Split Skin Donor Site Transcriptome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Digit Tip Wound
- Sponsor
- University Hospital Schleswig-Holstein
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- Differences in RNA-Expression pattern
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.
Detailed Description
Regrowth of amputated fingertips presents a unique regenerative healing process in mammals, with subcutaneous volume regrowth, restoration of the dactylogram, and suppression of scar formation. In addition, wound healing from split-thickness donor sites shows almost scar-free healing. Transcriptome analysis is necessary to better understand the specific healing mechanisms of these two wound entities. Since no data are available to date, this study aims to fill the gap.
Investigators
Tobias Kisch
Principal Investigator
University Hospital Schleswig-Holstein
Eligibility Criteria
Inclusion Criteria
- •Digit Tip Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Digit Tip Wound
- •Split Skin Donor Site Wound: Wound Exudate from healthy patients: Consent-capable patients ≥18 years of age with clean Split Skin Donor Site Wound
Exclusion Criteria
- •Inflammation
- •Borderline
- •Infectious Disease
Outcomes
Primary Outcomes
Differences in RNA-Expression pattern
Time Frame: 5 Weeks
Differences in RNA-Expression pattern between Digit Tip Wound and Split Skin Donor Site Wound