WEST-KOaST Study: WES (Whole Exome Sequencing) Analysis of Testicular Cancer Patientsand Their First-degree Family Members
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 4,500
- 主要终点
- Saliva biological sample
研究概览
简要总结
The project aims to identify the possible risk factors regarding the onset of the disease and to evaluate genes and gene modifications responsible for the onset od testicular cancer.
详细描述
Testicular tumor represents a relatively rare disease that hit young-adults men. It represents 1% of all male cancers and 5% of all urological male tumors. Its incidence grow year by year. In the field of the oncological research, the lack of knowledge about genes related to this disease represent a very relevant clinical question. For this reason this project aims to collect biological samples of saliva from testicular cancer patients and from their first-degree family members; demographic-clinical variables will be also collected in order to draft a comprehensive panel of genes and gene modifications related to the testicular cancer, combining this survey with a very detailed description of this cohort of patient in terms of clinical features and quality of life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male testicular cancer patients with an age > 18 and < 90
- •First degree family members of Male testicular cancer patients with an age > 18 and < 90
- •Ability to read and sign the informed consent
- •Diagnosis of testicular cancer for the experimental group
排除标准
- •Female for the experimental group
- •Second degree family members of Male testicular cancer patients
- •People with an age < 18 and > 90
- •Diagnosis different from testicular cancer for the experimental group Incapacity to read and sign the informed consent
结局指标
主要结局
Saliva biological sample
时间窗: Baseline
Saliva biological samples will be collected from both patients with testicular cancer and their first-degree family members trough a buccal swab, that will be analysed with a whole exome sequencing (WES) in order to explore panel of genes
次要结局
- Demographic-clinical variables(Baseline)
研究者
Andrea Salonia
Professor
IRCCS San Raffaele