WEST-KOaST Study: WES (Whole Exome Sequencing) Analysis of Testicular Cancer Patientsand Their First-degree Family Members
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Testicular Cancer
- Sponsor
- IRCCS San Raffaele
- Enrollment
- 4500
- Primary Endpoint
- Saliva biological sample
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The project aims to identify the possible risk factors regarding the onset of the disease and to evaluate genes and gene modifications responsible for the onset od testicular cancer.
Detailed Description
Testicular tumor represents a relatively rare disease that hit young-adults men. It represents 1% of all male cancers and 5% of all urological male tumors. Its incidence grow year by year. In the field of the oncological research, the lack of knowledge about genes related to this disease represent a very relevant clinical question. For this reason this project aims to collect biological samples of saliva from testicular cancer patients and from their first-degree family members; demographic-clinical variables will be also collected in order to draft a comprehensive panel of genes and gene modifications related to the testicular cancer, combining this survey with a very detailed description of this cohort of patient in terms of clinical features and quality of life.
Investigators
Andrea Salonia
Professor
IRCCS San Raffaele
Eligibility Criteria
Inclusion Criteria
- •Male testicular cancer patients with an age \> 18 and \< 90
- •First degree family members of Male testicular cancer patients with an age \> 18 and \< 90
- •Ability to read and sign the informed consent
- •Diagnosis of testicular cancer for the experimental group
Exclusion Criteria
- •Female for the experimental group
- •Second degree family members of Male testicular cancer patients
- •People with an age \< 18 and \> 90
- •Diagnosis different from testicular cancer for the experimental group Incapacity to read and sign the informed consent
Outcomes
Primary Outcomes
Saliva biological sample
Time Frame: Baseline
Saliva biological samples will be collected from both patients with testicular cancer and their first-degree family members trough a buccal swab, that will be analysed with a whole exome sequencing (WES) in order to explore panel of genes
Secondary Outcomes
- Demographic-clinical variables(Baseline)