Diaphragm paralysis; surgery or mechanical ventilation?

ZonMw0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•In order to be eligible to participate in this study, a participant must meet all of the following criteria:
•>18 years
•diagnosed with a unilateral or bilateral diaphragm paralysis based on isolated phrenic nerve injury.
•oUnilateral or bilateral diaphragm paralysis is defined as follows: complaints of dyspnea and / or orthopnea combined with a drop in VC of more than 15% when change from upright to supine position and a positive sniff test during fluoroscopy or ultrasonography. A positive sniff test means that the diaphragm stands still or even moves in cranial direction (paradoxical movement ) during the sniff inspiratory maneuver.
•Ability to provide written consent
•Time between diagnosis and treatment should be at least 1 year

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•Patients diagnosed with a unilateral or bilateral diaphragm paralysis due to a more systemic neurological or neuromuscular disorder like for example Amyotrophic Lateral Sclerosis ,
•Hypercapnia during daytime (PaCO2 > 6.0 kPa)
•Radiotherapy of the thorax
•Contra indication for diaphragm surgery.

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