Contribution Of Nuclear Magnetic Resonance Imaging In The Study Of Diabetic Cardiomyopathy
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- To quantify the myocardial blood flow at rest and after "cold pressor test" in a population of healthy volunteers
研究概览
简要总结
Diagnosis of diabetic cardiomyopathy is then retained, supposing a change in the coronary microcirculation linked to an endothelial dysfunction. Abnormalities of the myocardial metabolism is frequently associated. It is regrettably about a hypothesis difficult to verify with current medical techniques.This deficiency being not only harmful to the diagnosis, but also to the assessment of the efficiency of the medical treatment on the myocardial metabolism and the endothelial function. Techniques of nuclear magnetic resonance offer interesting perspectives.
详细描述
These techniques allow in this context:
- to quantify the myocardial blood flow at rest and after "cold pressor test" in a population of healthy volunteers. The myocardial blood flow will be obtained by estimating myocardial blood flow at the venous coronary sinus site. This allows us to quantify a possible endothelial dysfunction in a reproducible way. No MRI study in diabetic patients has ever been led until now with this technique.
- to estimate the metabolic and structural abnormalities in this population, with particularly:
- Quantification of the myocardial metabolism in vivo by spectrometry of phosphorus 31.
- Structural abnormalities: become integrated into the description of diabetic cardiomyopathy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •more than 18 years old
- •patient type 2 diabetes affects taken care more than 5 years to Timone Hospital
- •patient with a diabetic cardiomyopathy
- •informed and consented
排除标准
- •less than 18 years
- •Pregnant woman
- •patient type 1 diabetes affects
- •patient presents a cardiomyopathy mixed (no diabetic)
- •patients presents an arrhythmia ventriculaire or above - ventriculaire
- •Unstable hémodynamique patients
结局指标
主要结局
To quantify the myocardial blood flow at rest and after "cold pressor test" in a population of healthy volunteers
时间窗: 12 months
The myocardial blood flow will be obtained by estimating myocardial blood flow at the venous coronary sinus site. This allows us to quantify a possible endothelial dysfunction in a reproducible way. No MRI study in diabetic patients has ever been led until now with this technique.
次要结局
- To estimate the metabolic and structural abnormalities in this population(12 months)