Assessment of the Feasibility of Frozen Embryo Transfers in a Natural Cycle Among Obese Compared to Non-Obese Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,831
- 试验地点
- 1
- 主要终点
- feasibility of embryo transfer
研究概览
简要总结
This retrospective study included 1,831 single blastocyst frozen embryo transfer (FET) cycles performed between November 1, 2022 and August 31, 2025. Three endometrial preparation protocols were used according to ovulatory status, cycle duration, and characteristics of previous FET cycles: modified natural cycle with ovulation trigger (mNC-FET) (n = 770), stimulated cycle FET (SC-FET) (n = 468), and hormone replacement therapy FET (HRT-FET) (n = 593). In natural cycles, if the predefined criteria for ovulation trigger were not met, the cycle was converted to a stimulated cycle. The aim of this study was to determine whether body mass index affects embryo transfer feasibility, reproductive outcomes, and cycle characteristics across different FET protocols.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women aged ≥18 years at the time of frozen embryo transfer.
- •Patients undergoing assisted reproductive technology (ART) with frozen embryo transfer (FET) using a natural, modified natural, stimulated, or hormone replacement therapy (HRT) protocol.
- •Availability of body mass index (BMI) measurement prior to initiation of the treatment cycle.
排除标准
- 未提供
研究组 & 干预措施
Hormonal replacement therapy
干预措施: Hormonal replacement therapy (Procedure)
Modified natural cycle
干预措施: Modified natural cycle (Procedure)
Stimulated cycle
干预措施: Substitued cycle (Procedure)
结局指标
主要结局
feasibility of embryo transfer
时间窗: scheduled day of embryo transfer (Day 0 of planned FET cycle)
Proportion of treatment cycles in which the planned frozen embryo transfer (FET) was performed as scheduled, regardless of the number of embryos transferred.
次要结局
- Clinical pregnancy(6 weeks after embryo transfer)
- Miscarriage rate(12 weeks of gestation)
- Cycle cancellation rate(scheduled day of embryo transfer)
- Conversion from natural to stimulated cycles(time of treatment protocol modification during the stimulation phase (prior to ovulation trigger))