Assessment of the Feasibility of Frozen Embryo Transfers in a Natural Cycle Among Obese Compared to Non-Obese Patients
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Clinique Mathilde
- Enrollment
- 1,831
- Locations
- 1
- Primary Endpoint
- feasibility of embryo transfer
Overview
Brief Summary
This retrospective study included 1,831 single blastocyst frozen embryo transfer (FET) cycles performed between November 1, 2022 and August 31, 2025. Three endometrial preparation protocols were used according to ovulatory status, cycle duration, and characteristics of previous FET cycles: modified natural cycle with ovulation trigger (mNC-FET) (n = 770), stimulated cycle FET (SC-FET) (n = 468), and hormone replacement therapy FET (HRT-FET) (n = 593). In natural cycles, if the predefined criteria for ovulation trigger were not met, the cycle was converted to a stimulated cycle. The aim of this study was to determine whether body mass index affects embryo transfer feasibility, reproductive outcomes, and cycle characteristics across different FET protocols.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Women aged ≥18 years at the time of frozen embryo transfer.
- •Patients undergoing assisted reproductive technology (ART) with frozen embryo transfer (FET) using a natural, modified natural, stimulated, or hormone replacement therapy (HRT) protocol.
- •Availability of body mass index (BMI) measurement prior to initiation of the treatment cycle.
Exclusion Criteria
- Not provided
Arms & Interventions
Hormonal replacement therapy
Intervention: Hormonal replacement therapy (Procedure)
Modified natural cycle
Intervention: Modified natural cycle (Procedure)
Stimulated cycle
Intervention: Substitued cycle (Procedure)
Outcomes
Primary Outcomes
feasibility of embryo transfer
Time Frame: scheduled day of embryo transfer (Day 0 of planned FET cycle)
Proportion of treatment cycles in which the planned frozen embryo transfer (FET) was performed as scheduled, regardless of the number of embryos transferred.
Secondary Outcomes
- Clinical pregnancy(6 weeks after embryo transfer)
- Miscarriage rate(12 weeks of gestation)
- Cycle cancellation rate(scheduled day of embryo transfer)
- Conversion from natural to stimulated cycles(time of treatment protocol modification during the stimulation phase (prior to ovulation trigger))