3D Cohort Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 2,366
- 试验地点
- 1
- 主要终点
- Intrauterine growth restriction
研究概览
简要总结
The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children.
详细描述
The main objective of the 3D study is to create a large pregnancy and birth cohort, allowing for the assessment of the effects of combined prenatal exposure on both birth outcomes and longer-term infant and child health. The specific objectives are to:
- Determine the effects of pre- and post-natal exposures to environmental contaminants, nutritional factors and psychosocial stress on pregnancy and neurodevelopmental outcomes;
- Assess the contribution of social, genetic, epigenetic, nutritional and environmental factors to the etiology and outcomes of intrauterine growth restriction (IUGR) and preterm birth; and
- Assess the effects of assisted reproductive technologies (ART) on indicators of epigenetic modifications, and the relationship between such epigenetic changes and infant neurodevelopmental, cardiovascular, and metabolic outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Able to communicate in French or English
排除标准
- •Current intravenous drug use
- •Severe illnesses or life threatening conditions
- •Multiple gestation pregnancies
结局指标
主要结局
Intrauterine growth restriction
时间窗: At delivery
Birth weight smaller than 10th percentile
Neurodevelopment - Sensory Profile
时间窗: When infants are 2 years old
Neurodevelopmental assessment of the infant. Test used : Sensory Profile questionnaire. This test was done on 1520 children.
Preterm birth
时间窗: At delivery
Delivery before 37 weeks of gestation
Neurodevelopment - ABAS
时间窗: When infants are 2 years old
Neurodevelopmental assessment of the infant. Test used : Bayley Adaptive Behaviour Questionnaire (ABAS-II). This test was done on 1520 children.
Neurodevelopment - Bayley
时间窗: When infants are 2 years old
Neurodevelopmental assessment of the infant. Test used : Bayley Scales of Infant and Toddler Development (BSID-III; cognitive scale and motor scale combined). This test was done on 1520 children.
Neurodevelopment - MacArthur-Bates
时间窗: When infants are 2 years old
Neurodevelopmental assessment of the infant. Test used : MacArthur Communicative Development Inventories (CDI; French, English, Spanish and/or Mandarin). This test was done on 1520 children.
Neurodevelopment - M-CHAT
时间窗: When infants are 2 years old
Neurodevelopmental assessment of the infant. Test used : Modified Checklist of Autism in Toddlers (M-CHAT). This test was done on 1520 children.
次要结局
未报告次要终点
研究者
William Fraser
Professor
Université de Sherbrooke