Single-blind randomized control trial identify the effectiveness of electroconvulsive therapy (ECT) for patients with acute schizophrenia
- Conditions
- Acute schizophrenia
- Registration Number
- SLCTR/2019/010
- Lead Sponsor
- Sri Lanka Medical Association
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- Not specified
1. Male and female patients aged 18-60 years
2. Schizophrenia diagnosed by a consultant psychiatrist according to DSM-V criteria
3. Positive and Negative Syndrome Scale (PANSS) score >75 .
4. Patients who have not responded adequately to inpatient treatments in medication for 10 days
5. Patients who remain psychotic and disturbed after 10 days of treatment
1. Any contraindication for ECT (including medical conditions, raised intracranial pressure etc.)
2. Patients with prominent mood symptoms
3. Patients who are either dependent or have harmful use of psychoactive substances (alcohol or illicit drugs)
4. Patients who are non-compliant with medication
5. Any contraindication for general anaesthesia (including medical conditions)
6. The patients who are pregnant and lactating
7. Patients who do not have the capacity to give informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the change in mental illness severity using the Positive and Negative Syndrome Scale (PANSS) [Timepoint: weekly during the inpatient period and at week 1 and week 5 after discharge]<br>To assess the effect of illness on the participant’s day-to-day life on the Global Assessment of Functioning Scale (GAF) [Timepoint: weekly during the inpatient period and at week 1 and week 5 after discharge]<br>To assess the change in cognition as determined by the Montreal Cognitive Assessment (MoCA) [Timepoint: weekly during the inpatient period and at week 1 and week 5 after discharge]<br>
- Secondary Outcome Measures
Name Time Method one []<br>