To compare efficacy of high dose Vitamin C infusion and Thiamine (vitamin B1) infusion in patients of sepsis.

Sepsis is known as the main cause of death in critically ill patients and is responsible for one-third to half of the hospital mortalities. Sepsis is caused by an infectious organism, especially Gram-positive infections, which triggers a local immune response. The migration of neutrophils into the inflamed tissue will follow causing a release of free radicals and inflammatory mediators which may trigger, in some patients, a systemic inflammatory response syndrome (SIRS). SIRS may progress to severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS. Supplementation of vitamin C and thiamine in patients with sepsis remains an attractive therapeutic target, considering the potential benefits, low costs and favourable safety profile. Aim of the study is to compare the efficacy of vitamin c infusion with thiamine (vitamin B1) infusion in patients of sepsis.

This is a  prospective randomized double blind clinical study. Study will be conducted on 75 patient with sepsis admitted in intensive care unit . Patient will be randomized in 3 group 25 in each group. One group will receive injection vitamin C, one group will receive injection Thiamine and one group will receive placebo. Outcome  data will be analysed in terms of efficacy.