Central sensitization of chronic pain and itch: generalized and symptom-specific mechanisms.

• Conditions: atopic eczema; fibromyalgia; 10023213; pruritis sine materia; Rheumatoid arthritis; 10011063

• Registration Number: NL-OMON30317
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 384

Inclusion Criteria

Diagnosis of rheumatoid arthritis, atopic eczema, fibromyalgia or pruritis sine materia
Age of 18 years and older
Informed consent
Female gender

Exclusion Criteria

Severe physical and psychiatric comorbidity
Double diagnoses with regard to the conditions investigated
Pacemaker use
Pregnancy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The sensitivity for the different somatosensory stimuli is determined by<br /><br>measuring the thresholds of perception, pain and tolerance with in addition the<br /><br>symptom report by a 0 to 10 scale for itch and pain. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To control for the induced psychological stress, measures of autonomic arousal<br /><br>(heart rate variability, skin conductance and electromyografy) are additionally<br /><br>assessed during one experiment.</p><br>