Tracking Neural Synergies During Gait Rehabilitation After Stroke
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Shirley Ryan AbilityLab
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Change in Neural Synergies
- Status
- Active, not recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
The purpose of this study is to identify neural muscle synergies of patients post-stroke and track them during an inpatient acute rehabilitation. To this end, the researchers will use an innovative approach based on the identification of large populations of motor units from recordings of surface high-density electromyography (HD-EMG).
Detailed Description
The researchers will focus on the identification of neural muscle synergies of leg and thigh muscles during postural and locomotor tasks in patients post stroke. To this end, the researchers will recruit 20 patients participating in inpatient rehabilitation at Shirley Ryan AbilityLab in the early subacute phase after stroke and 20 age-matched healthy controls. The researchers will ask them to perform postural tasks and walking trials at their preferential speed. All assessments will be performed by a licensed physiotherapist as per the standard of care once a week during three weeks of inpatient rehabilitation at the Shirley Ryan AbilityLab. During these tasks, the researchers will record HD-EMG signals from four muscle groups (Quadriceps, Hamstrings, Triceps Surae, Tibialis anterior).
Investigators
Jose Pons
Principal Investigaor
Shirley Ryan AbilityLab
Eligibility Criteria
Inclusion Criteria
- •Age 18-85 years old
- •Ambulatory with or without an assistive device
- •Ability to stand unassisted for at least 15 min
- •Informed consent provided by participant
- •English speaking
Exclusion Criteria
- •Inability to communicate with researchers
- •Lower extremity joint pain, contractures
- •Major sensory deficits, or cardiovascular or respiratory symptoms contraindicative of walking
- •History or evidence of orthopedic, muscular, or physical disability
- •Taking current medications that may affect balance
- •History or evidence of vestibular, auditory, or proprioceptive impairment
- •History or indication of orthostatic hypotension
- •History of any neurological disease
- •Open wounds on surfaces in contact with HD-EMG electrodes
- •Concurrent participation in other lower limb research studies that according to the PI is likely to affect study outcome or confound results
Outcomes
Primary Outcomes
Change in Neural Synergies
Time Frame: Baseline and Once weekly, through completion of study up to 4 weeks
The neural synergies are group of muscles that receive a common input from the brain. The researchers will assess the common input as the level of correlated activity between muscles. The researchers will compare this level of correlated activity between legs and groups, and how this changes over the course of the study
Secondary Outcomes
- Step count(Each session, through completion of study up to 4 weeks)
- Change in stance time(Baseline and Once weekly, through completion of study up to 4 weeks)
- 10 Meter Walk Test(Baseline and Once weekly, through completion of study up to 4 weeks)
- 6 Minute Walk Test(Baseline and Once weekly, through completion of study up to 4 weeks)
- Quality Indicators(Baseline and Once weekly, through completion of study up to 4 weeks)
- Borg Rating of Perceived Exertion(Baseline and Once weekly, through completion of study up to 4 weeks)
- Age-predicted maximum heart rate zone(Each session, through completion of study up to 4 weeks)
- Functional Gait Assessment (FGA)(Baseline and Once weekly, through completion of study up to 4 weeks)
- Berg Balance Scale(Baseline and Once weekly, through completion of study up to 4 weeks)
- Change in step length(Baseline and Once weekly, through completion of study up to 4 weeks)
- Change in stride length(Baseline and Once weekly, through completion of study up to 4 weeks)
- Manual Muscle Test(Baseline and Once weekly, through completion of study up to 4 weeks)
- Modified Ashworth Scale(Baseline and Once weekly, through completion of study up to 4 weeks)
- Change in stride variability(Baseline and Once weekly, through completion of study up to 4 weeks)
- Change in cadence(Baseline and Once weekly, through completion of study up to 4 weeks)
- Passive Range of Motion(Baseline and Once weekly, through completion of study up to 4 weeks)
- Change in bilateral joint torque(Baseline and Once weekly, through completion of study up to 4 weeks)